ArticleNeural development2010
The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis.
Article in Neural development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 34 citations in OpenAlex.
- Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis.Molecules and cells · 2024Article
- The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development.Cells · 2023Review
- MyoD phosphorylation on multiple C terminal sites regulates myogenic conversion activity.Biochemical and biophysical research communications · 2016Article
- Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development.Genome biology · 2015Article
- Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate.Neural development · 2012Article
- Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination.Developmental biology · 2011Article
- The pharmacokinetics of enrofloxacin in adult African clawed frogs (Xenopus laevis).Journal of the American Association for Laboratory Animal Science : JAALAS · 2010Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe neural crest is a unique population of cells that arise in the vertebrate ectoderm at the neural plate border after which they migrate extensively throughout the embryo, giving rise to a wide range of derivatives. A number of proteins involved in neural crest development have dynamic expression patterns, and it is becoming clear that ubiquitin-mediated protein degradation is partly responsible for this.
resultsHere we demonstrate a novel role for the F-box protein Cdc4/Fbxw7 in neural crest development. Two isoforms of Xenopus laevis Cdc4 were identified, and designated xCdc4alpha and xCdc4beta. These are highly conserved with vertebrate Cdc4 orthologs, and the Xenopus proteins are functionally equivalent in terms of their ability to degrade Cyclin E, an established vertebrate Cdc4 target. Blocking xCdc4 function specifically inhibited neural crest development at an early stage, prior to expression of c-Myc, Snail2 and Snail.
conclusionsWe demonstrate that Cdc4, an ubiquitin E3 ligase subunit previously identified as targeting primarily cell cycle regulators for proteolysis, has additional roles in control of formation of the neural crest. Hence, we identify Cdc4 as a protein with separable but complementary functions in control of cell proliferation and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.