ReviewJournal of clinical hypertension (Greenwich, Conn.)2010
Compliance with the treatment of hypertension: the potential of combination therapy.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- The impact of fixed-dose combination versus free-equivalent combination therapies on adherence for hypertension: a meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- Single-pill vs free-equivalent combination therapies for hypertension: a meta-analysis of health care costs and adherence.Journal of clinical hypertension (Greenwich, Conn.) · 2011Pooled it
- Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects.Drug design, development and therapy · 2018Trial
- Antihypertensive response to combination of olmesartan and amlodipine does not depend on method and time of drug administration.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2013Trial
- Nutritional Discrepancies Among Inpatients and Outpatients Diagnosed with Hypertension.Healthcare (Basel, Switzerland) · 2024Article
- Dishing out the meds.The British journal of cardiology · 2024Article
- Combined management can decrease blood pressure: an investigation of health-seeking behaviors among hypertensive patients in urban communities in China.BMC cardiovascular disorders · 2021Article
- Larger Blood Pressure Reduction by Fixed-Dose Compared to Free Dose Combination Therapy of ACE Inhibitor and Calcium Antagonist in Hypertensive Patients.Translational medicine @ UniSa · 2017Article
- One year follow-up effect of renal sympathetic denervation in patients with resistant hypertension.ARYA atherosclerosis · 2016Article
- Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study.Drug design, development and therapy · 2016Article
- Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension.Vascular health and risk management · 2013Review
- How well do we care for patients with hypertension?Journal of clinical hypertension (Greenwich, Conn.) · 2012Review
- Perceptions of hypertension treatment among patients with and without diabetes.BMC family practice · 2012Article
- Catheter-based renal sympathetic denervation: chronic preclinical evidence for renal artery safety.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- New perspectives on chinese herbal medicine (zhong-yao) research and development.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- The polypill in the primary prevention of cardiovascular disease: cost-effectiveness in the Dutch population.BMJ open · 2011Article
- Influence of Integrated Chronic Disease Management Measures in Rural Medical Alliance on Health-Related Quality of Life of Hypertension Outpatients.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patient adherence to antihypertensive medication is vital to ensure the successful treatment of hypertension. Low levels of adherence to and persistence with prescribed therapy are major factors leading to the current poor rates of blood pressure control among patients with hypertension. There are many reasons for nonadherence to therapy including patient-, physician-, and therapy-related factors. Poor tolerability has a detrimental effect on adherence, therefore reducing the apparent effectiveness of agents with dose-dependent side effects. Various effective combination therapies are recommended by current guidelines, eg, beta-blocker plus calcium channel blocker (CCB), angiotensin receptor blocker (ARB) plus thiazide diuretic, angiotensin-converting enzyme (ACE) inhibitor plus thiazide diuretic, CCB plus thiazide diuretic, ACE inhibitor plus CCB, and ARB plus CCB, and these have the potential to increase adherence to therapy by combining a favorable tolerability profile with once-daily dosing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.