ArticleJournal of clinical hypertension (Greenwich, Conn.)2010
Treatment of hypertension in the inpatient setting: use of intravenous labetalol and hydralazine.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Executive Summary of the 2024 Philippine Clinical Practice Guidelines on the Diagnosis and Management of Acute Severe Blood Pressure Elevation.Journal of clinical hypertension (Greenwich, Conn.) · 2026Guideline
- Noncardiac inpatient has acute hypertension: Treat or not?The Journal of family practice · 2022Article
- Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Blood pressure response to commonly administered antihypertensives for severe inpatient hypertension.PloS one · 2022Article
- Pro Re Nata Antihypertensive Medications and Adverse Outcomes in Hospitalized Patients: A Propensity-Matched Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Identification of hypertension in hospitalized children prescribed as-needed antihypertensive medication.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Institutional Pathways to Improve Care of Patients with Elevated Blood Pressure in the Emergency Department.Current hypertension reports · 2018Review
- Retrospective review of the use of as-needed hydralazine and labetalol for the treatment of acute hypertension in hospitalized medicine patients.Therapeutic advances in cardiovascular disease · 2018Article
- An Update on Inpatient Hypertension Management.Current cardiology reports · 2015Review
- Current and newer agents for hypertensive emergencies.Current hypertension reports · 2014Review
- Acute hypertension: a systematic review and appraisal of guidelines.Ochsner journal · 2014Review
- Patients with hypertensive crises who are admitted to a coronary care unit: clinical characteristics and outcomes.Journal of clinical hypertension (Greenwich, Conn.) · 2013Article
- 48-year-old man with cough and leg swelling.Mayo Clinic proceedings · 2012Article
- Attitudes and practices of resident physicians regarding hypertension in the inpatient setting.Journal of clinical hypertension (Greenwich, Conn.) · 2010Article
- An audit of postoperative haemodynamic stability after intraoperative labetalol administration in non-cardiac surgery patients.Journal of perioperative practiceArticle
- Intravenous hydralazine for blood pressure management in the hospitalized patient: its use is often unjustified.Journal of the American Society of Hypertension : JASHArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute blood pressure elevations are commonly treated in hospitalized patients. There are no guidelines for appropriate practice and no evidence that such treatment is useful. The authors performed a retrospective review of medical and pharmacy records to determine how often intravenous hydralazine and labetalol are ordered and administered. During a 1-year study period, a total of 29,545 hospitalizations were recorded. The authors identified 2189 patients (7.4% of all patients) for whom 7242 orders were written for hydralazine as needed (10-20 mg per dose) and 5915 for labetalol (10-20 mg per dose). Ordered drugs were administered in 60.3% of patients, and the average number of doses administered was 5.3+/-8.2 (mean +/- SD) for hydralazine and 5.6+/-7.7 for labetalol. Hospital length of stay (LOS) for patients for whom hydralazine was ordered was 12.0+/-15.9 days for those who received at least 1 dose and 7.1+/-9.0 days for those who did not receive a dose (P<.001). For patients for whom labetalol was ordered, patients receiving at least 1 dose had an LOS of 11.8+/-16.1 days vs 7.9+/-10.4 days for those who did not receive a dose (P<.001). Treatment of elevated blood pressure in in-patients is a common practice. The authors suggest that evidence is needed to determine whether the practice is of benefit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.