Evidence map›Paper›PMID 20047609›Full record

Trial reportClinical transplantation

Metabolic syndrome and new onset diabetes after transplantation in kidney transplant recipients.

Fu L Luan, Eric Langewisch, Akinlolu Ojo

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Clinical transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489043 (Exercise, Prediabetes and Diabetes After Renal Transplantation.), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489043 naunknown statusnot on this map

Exercise, Prediabetes and Diabetes After Renal Transplantation.

TypeinterventionalSponsorHospital Universitario de CanariasRan2019 to 2021Enrolled60ConditionsDiabetes MellitusArmsExercise and healthy lifestyle recommendations
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 43 citations in OpenAlex.

  1. Early basal insulin therapy decreases new-onset diabetes after renal transplantation.Journal of the American Society of Nephrology : JASN · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Fu L LuanInternal Medicine, Division of Nephrology, University of Michigan Taubman Center, East Medical Center Drive, Ann Arbor, MI, USA. fluan@med.umich.edu
Eric Langewisch
Akinlolu Ojo
University of Michigan–Ann Arbor · US

Funding

Renal and Cardiovascular Events in Patients with Chronic Kidney DiseaseK24DK062234 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OJO, AKINLOLU OLUSEUN · 2002 to 2013
$1.6M
NIDDK NIH HHS K24 DK062234
6 · The paper itself

Abstract

backgroundMetabolic syndrome (MS) and new onset diabetes after transplant (NODAT) are common in kidney transplant patients. We studied the relationship between the two conditions and their impact on metabolic and cardiovascular risk profiles.

methodsAll non-diabetic patients transplanted between 1999 and 2005 who were followed up to 2006 were included. MS and NODAT were determined. Kaplan-Meier survival and various regression analyses were performed to determine the clinical correlates for both conditions and their association with various cardiovascular risk factors.

resultsAmong 591 patients, 314 (53.1%) had MS and 90 (15.2%) developed NODAT. The two conditions were highly associated with each other as 84 patients with NODAT also had MS (14.2%). Elevated body mass index and fasting glucose levels at transplant were risk factors for both conditions, whereas weight gain after transplant was associated only with MS. African American, old age, and hypertension-related ESRD were risk factors for NODAT. Finally, the presence of MS was associated with reduced kidney function and elevated uric acid levels, whereas the presence of NODAT with elevated pulse pressure.

conclusionsMS and NODAT are highly prevalent and significantly associated with impaired metabolic and cardiovascular risk profiles. Early identification of such conditions may facilitate targeted therapeutic intervention.

Indexed as

AdultCross-Sectional StudiesDiabetes MellitusFemaleHumansKidney TransplantationMaleMetabolic SyndromeMiddle AgedRetrospective StudiesRisk FactorsSurvival Rate

Identifiers

PMID20047609
PMCPMC3831507
OpenAlexW1491414474

What OpenQuestion holds

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LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.