ArticleJournal of physics. Condensed matter : an Institute of Physics journal2009
Quantifying DNA melting transitions using single-molecule force spectroscopy.
Article in Journal of physics. Condensed matter : an Institute of Physics journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
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Who cites it
23 citing papers in PubMed.
- Weak tension accelerates hybridization and dehybridization of short oligonucleotides.Nucleic acids research · 2023Article
- Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy.IEEE transactions on nanotechnology · 2019Article
- Unraveling the Thousand Word Picture: An Introduction to Super-Resolution Data Analysis.Chemical reviews · 2017Article
- Detecting the Biopolymer Behavior of Graphene Nanoribbons in Aqueous Solution.Scientific reports · 2016Article
- Single molecule force measurements of perlecan/HSPG2: A key component of the osteocyte pericellular matrix.Matrix biology : journal of the International Society for Matrix Biology · 2016Article
- Disturbance-free rapid solution exchange for magnetic tweezers single-molecule studies.Nucleic acids research · 2015Article
- A Single-Strand Annealing Protein Clamps DNA to Detect and Secure Homology.PLoS biology · 2015Article
- DNA under Force: Mechanics, Electrostatics, and Hydration.Nanomaterials (Basel, Switzerland) · 2015Review
- Article
- Data-driven techniques for detecting dynamical state changes in noisily measured 3D single-molecule trajectories.Molecules (Basel, Switzerland) · 2014Article
- Melting analysis on microbeads in rapid temperature-gradient inside microchannels for single nucleotide polymorphisms detection.Biomicrofluidics · 2014Article
- Quantifying transient 3D dynamical phenomena of single mRNA particles in live yeast cell measurements.The journal of physical chemistry. B · 2013Article
- Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels.Cell & bioscience · 2013Article
- Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Understanding the physics of DNA using nanoscale single-molecule manipulation.Frontiers of physics · 2012Article
- B-DNA to zip-DNA: simulating a DNA transition to a novel structure with enhanced charge-transport characteristics.The journal of physical chemistry. A · 2011Article
- Transition dynamics and selection of the distinct S-DNA and strand unpeeling modes of double helix overstretching.Nucleic acids research · 2011Article
- Improved high-force magnetic tweezers for stretching and refolding of proteins and short DNA.Biophysical journal · 2011Article
- Two distinct overstretched DNA states.Nucleic acids research · 2010Article
- P-SPLINES USING DERIVATIVE INFORMATION.Multiscale modeling & simulation : a SIAM interdisciplinary journal · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We stretched a DNA molecule using atomic force microscope and quantified the mechanical properties associated with B and S forms of double-stranded DNA (dsDNA), molten DNA, and single-stranded DNA (ssDNA). We also fit overdamped diffusion models to the AFM time series and used these models to extract additional kinetic information about the system. Our analysis provides additional evidence supporting the view that S-DNA is a stable intermediate encountered during dsDNA melting by mechanical force. In addition, we demonstrated that the estimated diffusion models can detect dynamical signatures of conformational degrees of freedom not directly observed in experiments.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.