ArticlePloS one2009
Monoamine oxidase A gene (MAOA) associated with attitude towards longshot risks.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Delayed reward discounting and addictive behavior: a meta-analysis.Psychopharmacology · 2011Pooled it
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Risk Attitude in the DuLong Minority Ethnicity of China.Frontiers in psychology · 2021Article
- Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees.PloS one · 2019Article
- Article
- The Role of Psychological and Physiological Factors in Decision Making under Risk and in a Dilemma.Frontiers in behavioral neuroscience · 2016Article
- An extended reinforcement learning model of basal ganglia to understand the contributions of serotonin and dopamine in risk-based decision making, reward prediction, and punishment learning.Frontiers in computational neuroscience · 2014Article
- Article
- The Promises and Pitfalls of Genoeconomics*Annual review of economics · 2012Article
- A combination of dopamine genes predicts success by professional Wall Street traders.PloS one · 2012Article
- MAOA-L carriers are better at making optimal financial decisions under risk.Proceedings. Biological sciences · 2011Article
- Molecular Genetics and Economics.The journal of economic perspectives : a journal of the American Economic Association · 2011Article
- Article
- Article
- Patrimony and the evolution of risk-taking.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decision making often entails longshot risks involving a small chance of receiving a substantial outcome. People tend to be risk preferring (averse) when facing longshot risks involving significant gains (losses). This differentiation towards longshot risks underpins the markets for lottery as well as for insurance. Both lottery and insurance have emerged since ancient times and continue to play a useful role in the modern economy. In this study, we observe subjects' incentivized choices in a controlled laboratory setting, and investigate their association with a widely studied, promoter-region repeat functional polymorphism in monoamine oxidase A gene (MAOA). We find that subjects with the high activity (4-repeat) allele are characterized by a preference for the longshot lottery and also less insurance purchasing than subjects with the low activity (3-repeat) allele. This is the first result to link attitude towards longshot risks to a specific gene. It complements recent findings on the neurobiological basis of economic risk taking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.