ReviewWiley interdisciplinary reviews. Systems biology and medicine
Systems analysis of bone.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications.Biomaterials translational · 2024Review
- Genetics of evolved load resistance in the skeletons of unusually large mice from Gough Island.Genetics · 2023Article
- Utility of HR-pQCT in detecting training-induced changes in healthy adult bone morphology and microstructure.Frontiers in physiology · 2023Review
- Macrophages: The Good, the Bad, and the Gluttony.Frontiers in immunology · 2021Review
- Muscle force interacts with stature to influence functionally related polar second moments of area in the lower limb among adult women.American journal of physical anthropology · 2020Article
- Age-related and sex-specific effects on architectural properties and biomechanical response of the C57BL/6N mouse femur, tibia and ulna.Bone reports · 2020Article
- Dissecting the Genetics of Osteoporosis using Systems Approaches.Trends in genetics : TIG · 2019Review
- Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Evaluation of the long-term skeletal effect induced by teratogen 5-aza-2'deoxycytidine on offspring of high (C3H/HeJ) and low (C57BL/6J) bone mass phenotype mice.Bone reports · 2018Article
- Bone up: craniomandibular development and hard-tissue biomineralization in neonate mice.Zoology (Jena, Germany) · 2017Article
- Synovial tissue macrophages: friend or foe?RMD open · 2017Review
- Thrombospondin-2 deficiency in growing mice alters bone collagen ultrastructure and leads to a brittle bone phenotype.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Women Build Long Bones With Less Cortical Mass Relative to Body Size and Bone Size Compared With Men.Clinical orthopaedics and related research · 2015Article
- Article
- Raman spectroscopy of soft musculoskeletal tissues.Applied spectroscopy · 2014Review
- Systematic evaluation of skeletal mechanical function.Current protocols in mouse biology · 2013Article
- Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Aging and bone.Journal of dental research · 2010Review
- Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The genetic variants contributing to variability in skeletal traits has been well studied, and several hundred QTLs have been mapped and several genes contributing to trait variation have been identified. However, many questions remain unanswered. In particular, it is unclear whether variation in a single gene leads to alterations in function. Bone is a highly adaptive system and genetic variants affecting one trait are often accompanied by compensatory changes in other traits. The functional interactions among traits, which is known as phenotypic integration, has been observed in many biological systems, including bone. Phenotypic integration is a property of bone that is critically important for establishing a mechanically functional structure that is capable of supporting the forces imparted during daily activities. In this paper, bone is reviewed as a system and primarily in the context of functionality. A better understanding of the system properties of bone will lead to novel targets for future genetic analyses and the identification of genes that are directly responsible for regulating bone strength. This systems analysis has the added benefit of leaving a trail of valuable information about how the skeletal system works. This information will provide novel approaches to assessing skeletal health during growth and aging and for developing novel treatment strategies to reduce the morbidity and mortality associated with fragility fractures.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.