ArticleIEEE transactions on nuclear science2009
Rapid Multi-Tracer PET Tumor Imaging With F-FDG and Secondary Shorter-Lived Tracers.
Article in IEEE transactions on nuclear science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Parametric imaging of dynamic long-axial-field-of-view PET scans: Technical challenges, statistical insights and clinical applications.Zeitschrift fur medizinische Physik · 2026Review
- Kinetic model-informed deep learning for multiplexed PET image separation.EJNMMI physics · 2024Article
- Signal separation of simultaneous dual-tracer PET imaging based on global spatial information and channel attention.EJNMMI physics · 2024Article
- Deep learned triple-tracer multiplexed PET myocardial image separation.Frontiers in nuclear medicine · 2024Article
- Simultaneous quantitative imaging of two PET radiotracers via the detection of positron-electron annihilation and prompt gamma emissions.Nature biomedical engineering · 2023Article
- Multiplexed imaging in oncology.Nature biomedical engineering · 2022Review
- Quantitation of multiple injection dynamic PET scans: an investigation of the benefits of pooling data from separate scans when mapping kinetics.Physics in medicine and biology · 2021Article
- Defining the Value of a Comparative Approach to Cancer Drug Development.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
- Application of separable parameter space techniques to multi-tracer PET compartment modeling.Physics in medicine and biology · 2016Article
- EM reconstruction of dual isotope PET using staggered injections and prompt gamma positron emitters.Medical physics · 2014Article
- Kinetic modeling in PET imaging of hypoxia.American journal of nuclear medicine and molecular imaging · 2014Review
- (18)F-alfatide II and (18)F-FDG dual-tracer dynamic PET for parametric, early prediction of tumor response to therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- Methodology for quantitative rapid multi-tracer PET tumor characterizations.Theranostics · 2013Review
- Single-scan dual-tracer FLT+FDG PET tumor characterization.Physics in medicine and biology · 2013Article
- Dual tracer imaging of SPECT and PET probes in living mice using a sequential protocol.American journal of nuclear medicine and molecular imaging · 2012Article
- Rapid Multi-Tracer PET Tumor Imaging With F-FDG and Secondary Shorter-Lived Tracers.IEEE transactions on nuclear science · 2009Article
- Evaluation of rapid dual-tracer (62)Cu-PTSM + (62)Cu-ATSM PET in dogs with spontaneously occurring tumors.Physics in medicine and biology · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Rapid multi-tracer PET, where two to three PET tracers are rapidly scanned with staggered injections, can recover certain imaging measures for each tracer based on differences in tracer kinetics and decay. We previously showed that single-tracer imaging measures can be recovered to a certain extent from rapid dual-tracer (62)Cu - PTSM (blood flow) + (62)Cu - ATSM (hypoxia) tumor imaging. In this work, the feasibility of rapidly imaging (18)F-FDG plus one or two of these shorter-lived secondary tracers was evaluated in the same tumor model. Dynamic PET imaging was performed in four dogs with pre-existing tumors, and the raw scan data was combined to emulate 60 minute long dual- and triple-tracer scans, using the single-tracer scans as gold standards. The multi-tracer data were processed for static (SUV) and kinetic (K(1), K(net)) endpoints for each tracer, followed by linear regression analysis of multi-tracer versus single-tracer results. Static and quantitative dynamic imaging measures of FDG were both accurately recovered from the multi-tracer scans, closely matching the single-tracer FDG standards (R > 0.99). Quantitative blood flow information, as measured by PTSM K(1) and SUV, was also accurately recovered from the multi-tracer scans (R = 0.97). Recovery of ATSM kinetic parameters proved more difficult, though the ATSM SUV was reasonably well recovered (R = 0.92). We conclude that certain additional information from one to two shorter-lived PET tracers may be measured in a rapid multi-tracer scan alongside FDG without compromising the assessment of glucose metabolism. Such additional and complementary information has the potential to improve tumor characterization in vivo, warranting further investigation of rapid multi-tracer techniques.
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Registered trials
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