ArticleIndian journal of pharmaceutical sciences
Effect of hydroxylpropyl-beta-cyclodextrin on Solubility of Carvedilol.
Article in Indian journal of pharmaceutical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 32 citations in OpenAlex.
- Sugar-Based Eutectic Systems Combined with Cyclodextrins for Enhanced Solubility of Carvedilol.Molecules (Basel, Switzerland) · 2026Article
- Cyclodextrin Complexation as a Way of Increasing the Aqueous Solubility and Stability of Carvedilol.Pharmaceutics · 2021Article
- Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits.Drug design, development and therapy · 2015Article
- Chitosan and chitosan chlorhydrate based various approaches for enhancement of dissolution rate of carvedilol.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-beta-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of carvedilol in the presence of 20% hydroxypropyl-beta-cyclodextrin at same pH values. It was observed that solubility of protonated form is more than neutral molecule. Hydroxypropyl-beta-cyclodextrin resulted in increased solubility at all the pH. But inclusion in the cavity of hydroxypropyl-beta-cyclodextrin might depend upon charge state of the molecule. So it can be concluded that solubility of carvedilol, can be increased either by the addition of hydroxypropyl-beta-cyclodextrin or by adding pH lowering agents. But both these methods if are to be used together, pH should be selected carefully.
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Registered trials
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