Evidence map›Paper›PMID 20046641›Full record

ArticleOxidative medicine and cellular longevity

Systemic oxidative stress is increased to a greater degree in young, obese women following consumption of a high fat meal.

Richard J Bloomer, Kelsey H Fisher-Wellman

Open access · hybridAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Protective effect of anti-oxidants on endothelial function in young Korean-Asians compared to Caucasians.Medical science monitor : international medical journal of experimental and clinical research · 2012
    Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Correlation between Oxidative Stress, Nutrition, and Cancer Initiation.International journal of molecular sciences · 2017
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. The effects of oxidative stress on female reproduction: a review.Reproductive biology and endocrinology : RB&E · 2012
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Richard J BloomerCardiorespiratory/Metabolic Laboratory, The University of Memphis, Memphis, Tennessee 38152, USA. rbloomer@memphis.edu
Kelsey H Fisher-Wellman
University of Memphis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High fat meals induce oxidative stress, which is associated with the pathogenesis of disease. Obese individuals have elevated resting biomarkers of oxidative stress compared to non-obese. We compared blood oxidative stress biomarkers in obese (n = 14; 30 +/- 2 years; BMI 35 +/- 1 kg x m(-2)) and non-obese (n = 16; 24 +/- 2 years; BMI 23 +/- 1 kg x m(-2)) women, in response to a high fat meal. Blood samples were collected pre-meal (fasted), and at 1, 2, 4 and 6 hours post meal, and assayed for trolox equivalent antioxidant capacity (TEAC), xanthine oxidase activity (XO), hydrogen peroxide (H(2)O(2)), malondialdehyde (MDA), triglycerides (TAG), and glucose. An obesity status effect was noted for all variables (p < 0.001; MDA p = 0.05), with obese women having higher values than non-obese, except for TEAC, for which values were lower. Time main effects were noted for all variables (p ≤ 0.01) except for TEAC and glucose, with XO, H(2)O(2), MDA and TAG increasing following feeding with a peak response at the four or six hour post feeding time point. While values tended to decline by six hours post feeding in the non-obese women (agreeing with previous studies), they were maintained (MDA) or continued to increase (XO, H(2)O(2) and TAG) in the obese women. While no interaction effects were noted (p > 0.05), contrasts revealed greater values in obese compared to non-obese women for XO, H(2)O(2), MDA, TAG and glucose, and lower values for TEAC at times from 1-6 hours post feeding (p ≤ 0.03). We conclude that young, obese women experience a similar pattern of increase in blood oxidative stress biomarkers in response to a high fat meal, as compared to non-obese women. However, the overall oxidative stress is greater in obese women, and values appear to remain elevated for longer periods of time post feeding. These data provide insight into another potential mechanism related to obesity-mediated morbidity.

Indexed as

Oxidative StressAdultBiomarkersBlood GlucoseBody Mass IndexDietary FatsFemaleHumansHydrogen PeroxideMalondialdehydeObesityTriglyceridesXanthine OxidaseBiomarkersBlood GlucoseDietary FatsHydrogen PeroxideMalondialdehydeTriglyceridesXanthine Oxidasebody massfree radicalsnutritionobesityoxidative stresstriglycerides

Identifiers

PMID20046641
PMCPMC2763227
OpenAlexW2059571578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.