ArticleDermato-endocrinology2009
The unfavorable effect of the A allele of the vitamin D receptor promoter polymorphism A-1012G has different mechanisms related to susceptibility and outcome of malignant melanoma.
Article in Dermato-endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Variants Fok1 and Bsm1 on VDR are associated with the melanoma risk: evidence from the published epidemiological studies.BMC genetics · 2015Pooled it
- Vitamin D receptor polymorphisms in patients with cutaneous melanoma.International journal of cancer · 2012Pooled it
- Association of Vitamin D receptor gene variations with Gastric cancer risk in Kashmiri population.Molecular biology reports · 2021Article
- Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate VariantNutrients · 2020Article
- Vitamin D receptor polymorphisms and melanoma.Oncology letters · 2019Review
- Germline determinants of clinical outcome of cutaneous melanoma.Pigment cell & melanoma research · 2016Review
- Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study.Carcinogenesis · 2016Article
- Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.Evolution, medicine, and public health · 2014Article
- Cytochromes p450 and skin cancer: role of local endocrine pathways.Anti-cancer agents in medicinal chemistry · 2014Review
- New vitamin D analogs as potential therapeutics in melanoma.Expert review of anticancer therapy · 2012Review
- Vitamin D receptor (VDR) polymorphisms and skin cancer: A systematic review.Dermato-endocrinology · 2011Article
- From the bench to emerging new clinical concepts: Our present understanding of the importance of the vitamin D endocrine system (VDES) for skin cancer.Dermato-endocrinology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The A allele of the A-1012G (rs4516035) vitamin D receptor (VDR) promoter polymorphism is associated with increased susceptibility and worsened outcome in malignant melanoma (MM). The A allele contains a GATA-3 binding site. There is a second polymorphism in the same promoter region, G-1520C (rs7139166), and there is potential for another GATA binding site in the G allele. Here, we tested the hypothesis that the G(-1520)A(-1012) haplotype might be a greater risk factor for MM than A-1012 alone. The A allele of A-1012G was preferentially linked to G of G-1520C and was more frequent in MM patients (p = 0.011) but G of G-1520C was not (p = 0.756). The CA haplotype was a very significant risk factor for MM (p = 0.0001) while the CG haplotype was protective (p = 0.014, combined model p = 0.00002). There was no effect of GA haplotype (p = 0.931), suggesting that that the difference in frequencies of the A allele between patients and controls was accounted for by the differences in frequencies of the CA haplotype. The A allele of A-1012G was more frequent in patients with metastasis (p = 0.054) than MM patients without metastasis, as was the G allele of G-1520C (p = 0.028). The GA haplotype was more frequent in patients with metastasis (p = 0.015), while frequencies of CA were similar. We suggest that the different roles of the A allele of A-1012G in susceptibility and metastasis risk may be a function of the availability of transcription factors in the differing cellular backgrounds related to susceptibility and progression of MM.
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