ArticlePsychiatry investigation2008
Three cases of reversible agranulocytosis after treatment with lamotrigine.
Article in Psychiatry investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Agranulocytosis Associated With Psychiatric Polypharmacy: Lessons Learned From a Clinical Case.Cureus · 2024Article
- Lamotrigine-induced neutropenia after high-dose concomitant initiation with phenytoin.Clinical case reports · 2021Article
- Are clozapine blood dyscrasias associated with concomitant medications?Innovations in clinical neuroscience · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several psychotropic drugs, including clozapine, are known to cause agranulocytosis and this may lead to a fatal condition. Lamotrigine is an anticonvulsant that the Food and Drug Administration (FDA) has approved for the depression of bipolar disorder. A few cases of lamotrigine-induced agranulocytosis have been previously reported on, but the pathophysiology and clinical manifestations are not yet known. This case series reports on 3 patients with different medical conditions who experienced agranulocytosis during treatment with lamotrigine. In these cases, the agranulocytosis occurred a few weeks after initiation of lamotrigine and it rapidly disappeared after discontinuation. We also discuss several characteristics of lamotrigine-induced agranulocytosis.
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