ArticlePsychiatry investigation2008
Serial Monitoring of Lead aVR in Patients with Prolonged Unconsciousness Following Tricyclic Antidepressant Overdose.
Article in Psychiatry investigation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Bizarre wide complex tachycardia caused by sodium channel toxicity secondary to the management of status epilepticus: Case report.Annals of medicine and surgery (2012) · 2022Article
- Toxicologic Confounders of Brain Death Determination: A Narrative Review.Neurocritical care · 2021Review
- A Case of Amitriptyline-induced Myocarditis.Cureus · 2018Article
- The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.International journal of nephrology · 2017Review
- Effect of intravenous midazolam on cardiac parameters in acute tricyclic antidepressants poisoning.ARYA atherosclerosis · 2016Article
- High Prevalence of Psychotropics Overdose among Suicide Attempters in Korea.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2015Article
- Complete absence of precordial R waves due to absence of left-sided pericardium.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2012Article
- Comment on "Serial monitoring of lead aVR in patients with prolonged unconsciousness following tricyclic antidepressant overdose".Psychiatry investigation · 2012Article
- The 'overly-sensitive' heart: sodium channel block and QRS interval prolongation.British journal of pharmacology · 2011Article
- Clinical value of lead aVR.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2011Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe cardiac and neurologic toxicities of tricyclic antidepressant (TCA) overdose have been reported since the introduction of TCAs in 1950s. Despite the decreased numbers of TCA overdoses, the mortality and morbidity rates of TCA overdose have remained constantly high. Clinical manifestations of TCA overdose are characterized by unconsciousness and specific electrocardiography (ECG) abnormalities such as prolongation of the PR and QTc intervals, widening of the QRS duration, and an increased R wave and R/S ratio in lead aVR. We report a case with unusually prolonged unconsciousness without initial stem reflexes for 7 days and multiple ECG abnormalities following TCA overdose. It is suggested that the serial monitoring of R wave and R/S ratio in lead aVR might be informative in predicting recovery from toxicity following TCA overdose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.