SynthesisCritical care medicine2009
Prolonged mechanical ventilation alters diaphragmatic structure and function.
Synthesis in Critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of the Display of Inspiratory Muscle Pressure Curves Estimated by Artificial Intelligence on the Ability of Health Care Professionals to Correctly Identify Patient-ventilator Asynchronies - Pmus Study
Effect of Early Extracorporeal Diaphragm Pacing （EDP） Combined With Tilt Table Verticalization （TTV) on Diaphragm Function in Critically Ill Patients With Mechanical Ventilation: a Randomized Controlled Trial.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.
- Diagnostic accuracy of lung ultrasound to predict weaning outcome: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Relationship of Ultrasonically Assessed Diaphragmatic Weakness with the Need for Postoperative Mechanical Ventilation in Older Adult Patients after Major Abdominal Surgeries: An Observational Study.Turkish journal of anaesthesiology and reanimation · 2026Article
- The impact of traumatic injury on the respiratory system; a narrative review of injury-associated and clinically-induced mechanisms of trauma-associated pneumonia.Frontiers in medicine · 2026Review
- Application of neurally adjusted ventilatory assist (NAVA): a narrative review.Journal of thoracic disease · 2025Review
- Cholesterol-Lowering Treatment Suppresses Neuromuscular Transmission Via Presynaptic Mechanism at the Mouse Diaphragm Muscle.Neurochemical research · 2025Article
- Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction.Experimental physiology · 2025Review
- Transformer-based multimodal precision intervention model for enhancing diaphragm function in elderly patients.Frontiers in computational neuroscience · 2025Article
- Tissue Doppler imaging of the diaphragm and outcome of weaning from mechanical ventilation.Australasian journal of ultrasound in medicine · 2024Article
- Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK.Journal of cellular and molecular medicine · 2024Article
- The Neuromechanics of Inspiratory Muscles in Mechanical Ventilation Liberation Success and Failure.Cureus · 2024Article
- Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury.Intensive care medicine experimental · 2023Review
- Modifiable risk factors for ventilator associated diaphragmatic dysfunction: a multicenter observational study.BMC pulmonary medicine · 2023Observational
- Critical care: A concept analysis.International journal of nursing sciences · 2023Review
- Safety and Feasibility of Noninvasive Electromagnetic Stimulation of the Phrenic Nerves.Respiratory care · 2023Article
- A simple-to-use nomogram for predicting prolonged mechanical ventilation for children after Ebstein anomaly corrective surgery: a retrospective cohort study.BMC anesthesiology · 2023Article
- The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Low Intensity Respiratory Muscle Training in COVID-19 Patients after Invasive Mechanical Ventilation: A Retrospective Case-Series Study.Biomedicines · 2022Article
- Respiratory plasticity following spinal cord injury: perspectives from mouse to man.Neural regeneration research · 2022Review
- Physiologic Effects of Prolonged Terminal Anesthesia in Sheep (Comparative medicine · 2022Article
- Aerosolized Surfactant for Preterm Infants with Respiratory Distress Syndrome.Children (Basel, Switzerland) · 2021Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology. MEASUREMENTS: Systematic literature review.
conclusionsProlonged mechanical ventilation can promote diaphragmatic atrophy and contractile dysfunction. As few as 18 hrs of mechanical ventilation results in diaphragmatic atrophy in both laboratory animals and humans. Prolonged mechanical ventilation is also associated with diaphragmatic contractile dysfunction. Studies using animal models revealed that mechanical ventilation-induced diaphragmatic atrophy is due to increased diaphragmatic protein breakdown and decreased protein synthesis. Recent investigations have identified calpain, caspase-3, and the ubiquitin-proteasome system as key proteases that contribute to mechanical ventilation-induced diaphragmatic proteolysis. The scientific challenge for the future is to delineate the mechanical ventilation-induced signaling pathways that activate these proteases and depress protein synthesis in the diaphragm. Future investigations that define the signaling mechanisms responsible for mechanical ventilation-induced diaphragmatic weakness will provide the knowledge required for the development of new medicines that can maintain diaphragmatic mass and function during prolonged mechanical ventilation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.