Evidence map›Paper›PMID 20045599›Full record

ArticleMagnetic resonance imaging2010

Initial in vivo rodent sodium and proton MR imaging at 21.1 T.

Victor D Schepkin, William W Brey, Peter L Gor'kov, Samuel C Grant

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Hardware Considerations for Preclinical Magnetic Resonance of the Kidney.Methods in molecular biology (Clifton, N.J.) · 2021
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  6. Functional Imaging Using Fluorine (Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  7. Magnetic Resonance Imaging in Tauopathy Animal Models.Frontiers in aging neuroscience · 2021
    Review
  8. Article
  9. Article
  10. Review
  11. Excitation and RF Field Control of a Human-Size 10.5-T MRI System.IEEE transactions on microwave theory and techniques · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Sodium 3D COncentration MApping (COMA 3D) using (23)Na and proton MRI.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Victor D SchepkinNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32310-4005, USA. schepkin@magnet.fsu.edu
William W Brey
Peter L Gor'kov
Samuel C Grant
Florida State University · USNational High Magnetic Field Laboratory · US

Funding

QUANTITATION OF HUMAN BRAIN TUMOR THERAPY RESPONSE BY MRP01CA085878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHNSON, TIMOTHY D · 2001 to 2017
$31.9M
Small Animal Imaging CoreP50CA093990 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2002 to 2012
$19.0M
Michigan Small Animal Imaging Resource (MSAIR)U24CA083099 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2007 to 2008
$1.3M
Dual Sodium MRI and Proton ADC Assessment of Rodent Glioma TherapyR21CA119177 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHEPKIN, VICTOR D. · 2006 to 2007
$314k
NCI NIH HHS P01 CA085878NCI NIH HHS P01-CA085878NCI NIH HHS P50 CA093990NCI NIH HHS P50-CA093990NCI NIH HHS R21 CA119177NCI NIH HHS R21-CA119177NCI NIH HHS U24 CA083099NCI NIH HHS U24-CA083099
6 · The paper itself

Abstract

The first in vivo sodium and proton magnetic resonance (MR) images and localized spectra of rodents were attained using the wide bore (105 mm) high resolution 21.1-T magnet, built and operated at the National High Magnetic Field Laboratory (Tallahassee, FL, USA). Head images of normal mice (C57BL/6J) and Fisher rats (approximately 250 g) were acquired with custom designed radiofrequency probes at frequencies of 237/900 MHz for sodium and proton, respectively. Sodium MR imaging resolutions of approximately 0.125 microl for mouse and rat heads were achieved by using a 3D back-projection pulse sequence. A gain in SNR of approximately 3 for sodium and approximately 2 times for proton were found relative to corresponding MR images acquired at 9.4 T. 3D Fast Low Angle Shot (FLASH) proton mouse images (50x50x50 microm(3)) were acquired in 90 min and corresponding rat images (100x100x100 microm(3)) within a total time of 120 min. Both in vivo large rodent MR imaging and localized spectroscopy at the extremely high field of 21.1 T are feasible and demonstrate improved resolution and sensitivity valuable for structural and functional brain analysis.

Indexed as

Brain ChemistryAnimalsBrainImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMiceMice, Inbred C57BLProtonsRatsRats, Inbred F344Reproducibility of ResultsSensitivity and SpecificitySodiumProtonsSodiumhigh magnetic fieldin vivo rodentlocalized spectroscopyMRIsodium

Identifiers

PMID20045599
PMCPMC2844785
OpenAlexW1972796316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.