ReviewSeminars in cell & developmental biology2010
The PARL family of mitochondrial rhomboid proteases.
Review in Seminars in cell & developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Regulation of mixotrophy inMicrobiology (Reading, England) · 2026Article
- Holding Out for a Model: Rhomboid Superfamily in Vertebrate Development and Disease.Journal of cellular physiology · 2025Review
- HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation.iScience · 2020Article
- Mitochondrial protein quality control: the mechanisms guarding mitochondrial health.Antioxidants & redox signaling · 2015Review
- Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese.Molecular genetics and genomics : MGG · 2015Article
- Rhomboid family gene expression profiling in breast normal tissue and tumor samples.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- PARL and HtrA2: another intricate ischemic neuronal apoptotic process starting within mitochondria.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Structure and mechanism of rhomboid protease.The Journal of biological chemistry · 2013Review
- Conformational change in rhomboid protease GlpG induced by inhibitor binding to its S' subsites.Biochemistry · 2012Article
- Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate.The Journal of biological chemistry · 2012Article
- Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis.PloS one · 2012Article
- Structural and mechanistic basis of Parl activity and regulation.Cell death and differentiation · 2011Article
- Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.The Journal of cell biology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Rhomboids are an ancient and conserved family of intramembrane-cleaving proteases, a small group of proteolytic enzymes capable of hydrolyzing a peptide bond within a transmembrane helix that anchors a substrate protein to the membrane. Mitochondrial rhomboids evolved in eukaryotes to coordinate a critical aspect of cell biology, the regulation of mitochondrial membranes dynamics. This function appears to have required the emergence of a structural feature that is unique among all other rhomboids: an additional transmembrane helix (TMH) positioned at the N-terminus of six TMHs that form the core proteolytic domain of all prokaryotic and eukaryotic rhomboids. This "1+6" structure, which is shared only among mitochondrial rhomboids, defines a subfamily of rhomboids with the prototypical family member being mammalian Parl. Here, we present the findings that in 11 years have elevated mitochondrial rhomboids as the gatekeepers of mitochondrial dynamics and apoptosis; further, we discuss the aspects of their biology that are bound to introduce new paradigm shifts in our understanding of how the organelle uses this unique type of protease to govern stress, signaling to the nucleus, and other key mitochondrial activities in health and disease.
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