ArticleToxicology and applied pharmacology2010
Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model.
Article in Toxicology and applied pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A systematic review and meta-analysis of bidirectional effect of arsenic on ERK signaling pathway.Molecular medicine reports · 2018Pooled it
- Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity.Molecular biology reports · 2021Review
- Arsenic Exposure and Compromised Protein Quality Control.Chemical research in toxicology · 2020Review
- Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells.Toxicology and applied pharmacology · 2017Article
- ATF2 partly mediated the expressions of proliferative factors and inhibited pro-inflammatory factors' secretion in arsenite-treated human uroepithelial cells.Toxicology research · 2017Article
- Cortical Astrocytes Acutely Exposed to the Monomethylarsonous Acid (MMANeurochemical research · 2016Article
- The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health.Environmental health perspectives · 2015Article
- The association of urine arsenic with prevalent and incident chronic kidney disease: evidence from the Strong Heart Study.Epidemiology (Cambridge, Mass.) · 2015Article
- Stat3 promotes invasion of esophageal squamous cell carcinoma through up-regulation of MMP2.Molecular biology reports · 2015Article
- Article
- Arsenic and Chronic Kidney Disease: A Systematic Review.Current environmental health reports · 2014Article
- Expression Of Selected Pathway-Marker Genes In Human Urothelial Cells Exposed Chronically To A Non-Cytotoxic Concentration Of Monomethylarsonous Acid.Toxicology reports · 2014Article
- Urine arsenic and prevalent albuminuria: evidence from a population-based study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2013Article
- Mechanisms by which interleukin-6 attenuates cell invasion and tumorigenesis in human bladder carcinoma cells.BioMed research international · 2013Article
- Cross-contamination of a UROtsa stock with T24 cells--molecular comparison of different cell lines and stocks.PloS one · 2013Article
- Transcriptional Modulation of the ERK1/2 MAPK and NF-κB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer.Journal of cancer research updates · 2012Article
- Arsenite activates NFκB through induction of C-reactive protein.Toxicology and applied pharmacology · 2012Article
- Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid.Toxicology · 2012Article
- Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells.Toxicology and applied pharmacology · 2012Article
- BCG response prediction with cytokine gene variants and bladder cancer: where we are?Journal of cancer research and clinical oncology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Human bladder cancer has been associated with chronic exposure to arsenic. Chronic exposure of an immortalized non-tumorigenic urothelial cell line (UROtsa cells) to arsenicals has transformed these cells to a malignant phenotype, but the involved mechanisms are not fully understood. Chronic inflammation has been linked with cancer development mainly because many pro-inflammatory cytokines, growth factors as well as angiogenic chemokines have been found in tumors. In this study the chronology of inflammatory cytokines production was profiled in UROtsa cells chronically exposed to the toxic arsenic metabolite, monomethylarsonous acid [50 nM MMA(III)] to know the role of inflammation in cell transformation. Acute 50 nM MMA(III) exposure induced over-production of many pro-inflammatory cytokines as soon as 12 h after acute exposure. The same cytokines remain over-regulated after chronic exposure to 50 nM MMA(III), especially after 3 mo exposure. At 3 mo exposure the sustained production of cytokines like IL-1, IL-6, IL-8 and TNF is coincident with the appearance of characteristics associated with cell transformation seen in other arsenic-UROtsa studies. The sustained and increased activation of NFkappaB and c-Jun is also present along the transformation process and the phosphorylated proteins p38 MAPK and ERK 1/2 are increased also through the time line. Taken together these results support the notion that chronic inflammation is associated within MMA(III)-induced cell transformation and may act as a promoting factor in UROtsa cell transformation.
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