ArticleCurrent biology : CB2010
Transcriptional orchestration of the regulated secretory pathway in neurons by the bHLH protein DIMM.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- A high-resolution atlas of the brain predicts lineage and birth order underlying neuronal identity.Cell genomics · 2026Article
- Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity.PLoS biology · 2025Article
- Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021Review
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Genetic Underpinnings of Host Manipulation byG3 (Bethesda, Md.) · 2020Article
- A single-cell transcriptomic atlas of the adulteLife · 2020Article
- Neuropeptide Mapping of Dimmed Cells of Adult Drosophila Brain.Journal of the American Society for Mass Spectrometry · 2018Article
- Shep regulatesDevelopment (Cambridge, England) · 2018Article
- Control of protein translation by IPFly · 2017Article
- Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.PLoS genetics · 2017Article
- A single transcription factor is sufficient to induce and maintain secretory cell architecture.Genes & development · 2017Article
- Transcriptional Reorganization ofFrontiers in molecular neuroscience · 2017Article
- TheFrontiers in molecular neuroscience · 2016Article
- A serial multiplex immunogold labeling method for identifying peptidergic neurons in connectomes.eLife · 2015Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- The Drosophila Prosecretory Transcription Factor dimmed Is Dynamically Regulated in Adult Enteroendocrine Cells and Protects Against Gram-Negative Infection.G3 (Bethesda, Md.) · 2015Article
- Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED.Nucleic acids research · 2015Article
- Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster.Genetics · 2014Article
- Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe Drosophila basic helix-loop-helix (bHLH) gene dimmed (dimm) promotes a neurosecretory/neuroendocrine phenotype in cells but is not associated with specific neuropeptides or neurohormones. Rather, it is expressed by those peptidergic neurons that project long axons and appear to produce large amounts of secretory peptides. Here, we genetically transform nonpeptidergic neurons in Drosophila to study DIMM's action mechanisms.
resultsNonpeptidergic neurons normally fail to accumulate ectopic neuropeptides. We now show that they will do so when they are also forced to express ectopic DIMM. Furthermore, mass spectrometry shows that photoreceptors, which are normally nonpeptidergic, fail to process an ectopic neuropeptide precursor to make bioactive peptides but will do so efficiently when DIMM is co-misexpressed. Likewise, photoreceptors, which normally package the fast neurotransmitter histamine within small clear synaptic vesicles, produce numerous large dense-core vesicles (LDCVs) when they misexpress DIMM. These novel LDCVs accumulate ectopic neuropeptide when photoreceptors co-misexpress a neuropeptide transgene. DIMM-expressing photoreceptors no longer accumulate histamine and lose synaptic organelles critical to their normal physiology.
conclusionsThese findings indicate that DIMM suppresses conventional fast neurotransmission and promotes peptidergic neurosecretory properties. We conclude that DIMM normally provides a comprehensive transcriptional control to direct the differentiation of dedicated neuroendocrine neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.