ArticleCurrent biology : CB2010
Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Spontaneous Mutations Occur More in Highly Transcribed Regions in Daphnia.Genome biology and evolution · 2026Article
- The landscape and driver potential of site-specific hotspots across cancer genomes.NPJ genomic medicine · 2021Article
- Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer.Photochemistry and photobiology · 2020Review
- Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI).Science (New York, N.Y.) · 2017Article
- Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions.The Journal of cell biology · 2015Article
- Mechanisms underlying mutational signatures in human cancers.Nature reviews. Genetics · 2014Review
- Understanding nucleotide excision repair and its roles in cancer and ageing.Nature reviews. Molecular cell biology · 2014Review
- Transcription-associated mutagenesis.Annual review of genetics · 2014Review
- High levels of transcription stimulate transversions at GC base pairs in yeast.Environmental and molecular mutagenesis · 2013Article
- Genomic evidence for elevated mutation rates in highly expressed genes.EMBO reports · 2012Article
- Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells.Nucleic acids research · 2012Article
- UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.Nature genetics · 2012Article
- Transcription as a source of genome instability.Nature reviews. Genetics · 2012Review
- The transcript-centric mutations in human genomes.Genomics, proteomics & bioinformatics · 2012Article
- Measuring the formation and repair of UV damage at the DNA sequence level by ligation-mediated PCR.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Transcription inhibition by DRB potentiates recombinational repair of UV lesions in mammalian cells.PloS one · 2011Article
- Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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8 authors at 1 institution in 1 country.
Funding
Abstract
Skin cancer is the most ubiquitous cancer type in the Caucasian population, and its incidence is increasing rapidly [1]. Transcribed proliferation-related genes in dermal stem cells are targets for the induction of ultraviolet light (UV)-induced mutations that drive carcinogenesis. We have recently found that transcription of a gene increases its mutability by UV in mammalian stem cells, suggesting a role of transcription in skin carcinogenesis [2]. Here we show that transcription-associated UV-induced nucleotide substitutions are caused by increased deamination of cytosines to uracil within photolesions at the transcribed strand, presumably at sites of stalled transcription complexes. Additionally, via an independent mechanism, transcription of UV-damaged DNA induces the generation of intragenic deletions. We demonstrate that transcription-coupled nucleotide excision repair (TC-NER) provides protection against both classes of transcription-associated mutagenesis. Combined, these results unveil the existence of two mutagenic pathways operating specifically at the transcribed DNA strand of active genes. Moreover, these results uncover a novel role for TC-NER in the suppression of UV-induced genome aberrations and provide a rationale for the efficient induction of apoptosis by stalled transcription complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.