ArticleCurrent biology : CB2010
Requirement for an enzymatic visual cycle in Drosophila.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 93 citations in OpenAlex.
- Loss of calcium-binding proteinbioRxiv : the preprint server for biology · 2026Article
- Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium.BMC biology · 2023Article
- A Non-Gradual Development Process of Cicada Eyes at the End of the Fifth-Instar Nymphal Stage to Obtain Visual Ability.Insects · 2022Article
- Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types.Communications biology · 2022Article
- The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye.Development (Cambridge, England) · 2022Article
- A Drosophila perspective on retina functions and dysfunctions.Neural regeneration research · 2022Article
- Non-visual Opsins and Novel Photo-Detectors in the Vertebrate Inner Retina Mediate Light Responses Within the Blue Spectrum Region.Cellular and molecular neurobiology · 2022Review
- The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes.BMC ecology and evolution · 2021Article
- A DREaMR system to simplify combining mutations with rescue transgenes in Aedes aegypti.Genetics · 2021Article
- Semper's cells in the insect compound eye: Insights into ocular form and function.Developmental biology · 2021Review
- Vitamin A deficiency affects gene expression in the Drosophila melanogaster head.G3 (Bethesda, Md.) · 2021Article
- Mechanisms of vitamin A metabolism and deficiency in the mammalian and fly visual system.Developmental biology · 2021Review
- Molecular components affecting ocular carotenoid and retinoid homeostasis.Progress in retinal and eye research · 2021Review
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- Dark-adaptation in the eyes of a lake and a sea population of opossum shrimp (Mysis relicta): retinoid isomer dynamics, rhodopsin regeneration, and recovery of light sensitivity.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs).Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- Protein Phosphatase 2A and Clathrin-Mediated Endocytosis Facilitate Robust Melanopsin Light Responses and Resensitization.Investigative ophthalmology & visual science · 2020Article
- Pulse magnetization elicits differential gene expression in the central nervous system of the Caribbean spiny lobster, Panulirus argus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- The genetic basis of diurnal preference in Drosophila melanogaster.BMC genomics · 2020Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe visual cycle is an enzymatic pathway employed in the vertebrate retina to regenerate the chromophore after its release from light-activated rhodopsin. However, a visual cycle is thought to be absent in invertebrates such as the fruit fly Drosophila melanogaster.
resultsWe demonstrate that an enzymatic visual cycle exists in flies for chromophore regeneration and requires a retinol dehydrogenase, PDH, in retinal pigment cells. Absence of PDH resulted in progressive light-dependent loss of rhodopsin and retinal degeneration. These defects are suppressed by introduction of a mammalian dehydrogenase, RDH12, which is required in humans to prevent retinal degeneration. We demonstrate that a visual cycle is required in flies to sustain a visual response under nutrient deprivation conditions that preclude de novo production of the chromophore.
conclusionsOur results demonstrate that an enzymatic visual cycle exists and is required in flies for maintaining rhodopsin levels. These findings establish Drosophila as an animal model for studying the visual cycle and retinal diseases associated with chromophore regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.