ArticleBMC infectious diseases2010
Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 231 citations in OpenAlex.
- Procalcitonin contributes to hippocampal neuronal damage and impairment of LTP: implications for cognitive dysfunction in LPS-induced neuroinflammation rat model.Archives of microbiology · 2025Article
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- COVID-19 preventive behaviors and influencing factors in the Iranian population; a web-based survey.BMC public health · 2021Article
- Developing a newborn rat model of ventriculitis without concomitant bacteremia by intraventricular injection of K1 (-) Escherichia coli.Pediatrics international : official journal of the Japan Pediatric Society · 2020Article
- The inflammatory response and neuronal injury in Streptococcus suis meningitis.BMC infectious diseases · 2018Article
- Role of neural barriers in the pathogenesis and outcome ofExperimental and therapeutic medicine · 2017Article
- Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.Scientific reports · 2017Article
- Preventive behaviors by the level of perceived infection sensitivity during the Korea outbreak of Middle East Respiratory Syndrome in 2015.Epidemiology and health · 2016Article
- Increase in hippocampal water diffusion and volume during experimental pneumococcal meningitis is aggravated by bacteremia.BMC infectious diseases · 2014Article
- Long-term effects from bacterial meningitis in childhood and adolescence on postural control.PloS one · 2014Article
- Role of the cathelicidin-related antimicrobial peptide in inflammation and mortality in a mouse model of bacterial meningitis.Journal of innate immunity · 2014Article
- Pathogenesis and pathophysiology of pneumococcal meningitis.Clinical microbiology reviews · 2011Review
- Distributed, limbic gray matter atrophy in patients after bacterial meningitis.AJNR. American journal of neuroradiologyArticle
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteremia and systemic complications both play important roles in brain pathophysiological alterations and the outcome of pneumococcal meningitis. Their individual contributions to the development of brain damage, however, still remain to be defined.
methodsUsing an adult rat pneumococcal meningitis model, the impact of bacteremia accompanying meningitis on the development of hippocampal injury was studied. The study comprised of the three groups: I. Meningitis (n = 11), II. meningitis with attenuated bacteremia resulting from iv injection of serotype-specific pneumococcal antibodies (n = 14), and III. uninfected controls (n = 6).
resultsPneumococcal meningitis resulted in a significantly higher apoptosis score 0.22 (0.18-0.35) compared to uninfected controls (0.02 (0.00-0.02), Mann Whitney test, P = 0.0003). Also, meningitis with an attenuation of bacteremia by antibody treatment resulted in significantly reduced apoptosis (0.08 (0.02-0.20), P = 0.01) as compared to meningitis.
conclusionsOur results demonstrate that bacteremia accompanying meningitis plays an important role in the development of hippocampal injury in pneumococcal meningitis.
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