ArticleJournal of women's health (2002)2009
Metabolic syndrome and elevated C-reactive protein in breast cancer survivors on adjuvant hormone therapy.
Article in Journal of women's health (2002), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01954706 (Pilot Trial of Aerobic and Resistance Exercise Training for the Primary Prevention of Musculoskeletal Side Effects From Aromatase Inhibitors in Postmenopausal Breast Cancer Patients), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Trial of Aerobic and Resistance Exercise Training for the Primary Prevention of Musculoskeletal Side Effects From Aromatase Inhibitors in Postmenopausal Breast Cancer Patients
Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Trial
- The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors--a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Trial
- Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial.Breast cancer research and treatment · 2011Trial
- Long-term effects of aromatase inhibitors on body mass index among postmenopausal breast cancer survivors in Africa: observational cohort study.BMC research notes · 2023Observational
- Chemotherapeutic drug screening in 3D-Bioengineered human myobundles provides insight into taxane-induced myotoxicities.iScience · 2022Article
- Metabolic syndrome and breast cancer survivors: a follow-up analysis after completion of chemotherapy.Diabetology & metabolic syndrome · 2022Article
- Reducing Metabolic Dysregulation in Obese Latina and/or Hispanic Breast Cancer Survivors Using Physical Activity (ROSA) Trial: A Study Protocol.Frontiers in oncology · 2022Article
- C-Reactive Protein and Cancer-Diagnostic and Therapeutic Insights.Frontiers in immunology · 2020Review
- Impaired fasting glucose in breast cancer survivors of a general hospital at Mexico City: A case series study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- Cardiovascular and Cancer Risk: The Role of Cardio-oncology.Journal of the advanced practitioner in oncology · 2018Review
- Physical Activity, Weight Control, and Biomarkers of Prognosis and Survival among Breast Cancer Survivors.Archives of epidemiology · 2018Article
- Observational
- Observational
- Increased depression and metabolic risk in postmenopausal breast cancer survivors.Diabetology & metabolic syndrome · 2016Article
- Design of a randomised intervention study: the effect of dumbbell exercise therapy on physical activity and quality of life among breast cancer survivors in Malaysia.BMJ global health · 2016Article
- Single subject design: Use of time series analyses in a small cohort to understand adherence with a prescribed fluid restriction.Applied nursing research : ANR · 2015Article
- C-Reactive Protein and Breast Cancer: New Insights from Old Molecule.International journal of breast cancer · 2015Review
- Increased cardiovascular risk factors in breast cancer survivors identified by routine measurements of body composition, resting heart rate and arterial blood pressure.SpringerPlus · 2014Article
- Metabolic syndrome in Mexican women survivors of breast cancer: a pilot study at a general hospital.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2014Article
- Exercise after diagnosis and metabolic syndrome among breast cancer survivors: a report from the Shanghai Breast Cancer Survival Study.Cancer causes & control : CCC · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsAs the efficacy of treatment for breast cancer has improved, particularly with the use of antiestrogenic therapies, there is an increasing population of long-term breast cancer survivors who seeks care with unique health issues. These patients may be at increased risk for cardiovascular disease (CVD) resulting from excess adiposity and treatment effects. Metabolic syndrome (MetS) and elevated C-reactive protein (CRP), two predictors of CVD, have not been fully evaluated in overweight breast cancer survivors on hormone-modulating agents.
methodsAnthropometric measures, including weight, height, waist and hip circumferences; clinical laboratory assessments, including lipids, glucose, glycoslyated hemoglobin (HbA1c), insulin, and high sensitivity CRP; and body composition and blood pressure (BP) were collected from overweight breast cancer survivors (n=42). Select measures were used to derive MetS using the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) diagnostic criteria.
resultsParticipants had a mean body weight of 83.8 kg and body mass index (BMI) of 31.4 kg/m2. Mean fasting glucose (98+/-12.9 mg/dL), HbA1c (6.0+/-0.5 mg/dL), cholesterol (199+/-33.7 mg/dL), and insulin (16+/-3.2 mg/dL) were all at the upper end of the normal range. MetS was diagnosed in 54.8% of overweight postmenopausal breast cancer survivors. CRP was moderately or severely elevated in 90.5% of the population (mean of 5.1+/-5.3 mg/dL).
conclusionsIn our sample, overweight breast cancer survivors commonly have MetS and elevated CRP that place them at increased risk for cardiovascular and other metabolic diseases. If replicated in a larger sample, this warrants close medical monitoring to prevent and reduce morbidity and mortality unrelated to breast cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.