ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
The tbx/bHLH transcription factor mga regulates gata4 and organogenesis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer's Disease.International journal of molecular sciences · 2023Article
- The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates.International journal of molecular sciences · 2023Review
- Review
- Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.eLife · 2021Article
- Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish.Frontiers in cell and developmental biology · 2018Article
- Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer.Journal of translational medicine · 2015Article
- Mga is essential for the survival of pluripotent cells during peri-implantation development.Development (Cambridge, England) · 2015Article
- Article
- Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators.Development (Cambridge, England) · 2011Article
- Differential gene expression profiling implicates altered network development in rat postnatal day 4 cortex following 4-Methylimidazole (4-MeI) induced maternal seizures.Neurotoxicology and teratologyArticle
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2 authors at 1 institution in 1 country.
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Abstract
The mga gene encodes a unique transcription factor containing both TBOX and bHLHzip DNA-binding domains. Here we describe the structure, expression pattern, and loss-of-function phenotype for zebrafish mga. The mga gene is conserved with mammalian homologs for both DNA-binding domains. It is expressed maternally, and subsequently in the developing brain, heart, and gut, and its depletion causes morphogenetic defects in each of these organ systems. The heart and gut phenotypes are similar to those described previously for loss of gata4, and the mga morphant shows increased levels of gata4 transcripts in lateral mesoderm. Knockdown of gata4 rescues the early heart-looping defect (but not the gut defect), indicating that mga restricts the normal levels of Gata4 required for heart tube looping, while both genes are important for gut development. Transcript profiling experiments show that mga functions early to influence key regulators of mesendoderm, including tbx6, cas, and sox17.
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