ArticleAmerican journal of hypertension2010
Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database.
Article in American journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.
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16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Computational resources associating diseases with genotypes, phenotypes and exposures.Briefings in bioinformatics · 2019Pooled it
- Genetic association studies of endothelial nitric oxide synthase gene polymorphisms in women with unexplained recurrent pregnancy loss: a systematic and meta-analysis.Molecular biology reports · 2014Pooled it
- β1-adrenoceptor gene Arg389Gly polymorphism and essential hypertension risk in general population: a meta-analysis.Molecular biology reports · 2013Pooled it
- The β1-adrenoreceptor gene Arg389Gly and Ser49Gly polymorphisms and hypertension: a meta-analysis.Molecular biology reports · 2013Pooled it
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.Nature genetics · 2011Pooled it
- Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system.BMC medicine · 2011Pooled it
- Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure.Frontiers in cardiovascular medicine · 2023Article
- Article
- Germline genetic variants with implications for disease risk and therapeutic outcomes.Physiological genomics · 2017Review
- A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women.British journal of clinical pharmacology · 2014Article
- Orthostatic blood pressure dysregulation and polymorphisms of β-adrenergic receptor genes in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- EINVis: a visualization tool for analyzing and exploring genetic interactions in large-scale association studies.Genetic epidemiology · 2013Article
- Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in Black adolescents and young adults.Psychophysiology · 2012Article
- Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.Current hypertension reports · 2012Review
- Recent findings in the genetics of blood pressure and hypertension traits.American journal of hypertension · 2011Review
- Morphine-mediated alteration of hypertension-related gene expression in human white blood cells and multilineage progenitor cells.Journal of human hypertension · 2010Article
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2 authors at 2 institutions in 2 countries.
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Abstract
backgroundThe adrenergic receptor (adrenoceptor) family genes have been extensively studied as candidate genes in hypertension but the results of individual genetic association studies (GAS) are controversial and inconclusive. To clarify these data, a systematic assessment of GAS for adrenoceptor family genes in hypertension was conducted.
methodsData from 163 GAS involving 7 genes and 37 distinct genetic variants were analyzed and cataloged in CUMAGAS-HYPERT (Cumulative Meta-analysis of Genetic Association Studies-HYPERTension; a web-based information system, which allows the retrieval and synthesis of data from GAS in hypertension, available at http://biomath.med.uth.gr). Data from genome-wide association studies involving the adrenoceptor family genes were also systematically searched.
resultsIndividual GAS reported inconsistent associations and had limited power to detect modest genetic effects, with only 1.2% having power >80%. Thirteen variants were investigated by three or more studies and their results were subject to meta-analysis. In the main meta-analyses, significant results were shown for five variants (ADRB1 p.Arg389Gly, ADRB1 p.Ser49Gly, ADRB2 g.9368308A>G, ADRB3 p.Trp64Arg, and ADRA1A p.Cys347Arg) under the allelic contrast and/or the dominant model. Subgroup analyses by ethnicity and gender detected significant associations for three variants (ADRB1 p.Arg389Gly in east Asians, ADRB2 p.Gln27Glu in whites, and ADRB3 p.Trp64Arg in whites and in males). Heterogeneity ranged from none to high. No significant associations were recorded from genome-wide studies.
conclusionsThere is evidence to implicate adrenoceptor genes in hypertension, although future studies designed to investigate epistatic and gene-environment interactions would allow more solid conclusions to be drawn about the role of these genes in hypertension.
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