ArticleAJNR. American journal of neuroradiology2010
Functional contrast-enhanced CT for evaluation of acute ischemic stroke does not increase the risk of contrast-induced nephropathy.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Guideline on the use of iodinated contrast media in patients with kidney disease 2018.Clinical and experimental nephrology · 2020Guideline
- Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version : JSN, JRS, and JCS Joint Working Group.Clinical and experimental nephrology · 2013Guideline
- Guidelines on the use of iodinated contrast media in patients with kidney disease 2012: digest version. JSN, JRS, and JCS Joint Working Group.Japanese journal of radiology · 2013Guideline
- Effect of Contrast-Enhanced CT Brain on Renal Function in Potential Intraarterial Therapy Patients in the Emergency Department.Emergency medicine international · 2026Article
- Incidence of acute kidney injury in patients with acute ischaemic stroke undergoing CT angiography (CTA) and CT perfusion (CTP): a systematic review and meta-analysis.BMJ neurology open · 2024Article
- Prevention of post-contrast kidney injury in patients with cancer.Drugs in context · 2024Review
- Changes in blood and renal function in patients after cerebral digital subtraction angiography.Research in diagnostic and interventional imaging · 2023Article
- Minimal Imaging Requirements.Journal of neuroendovascular therapy · 2023Review
- Contrast-Induced Acute Kidney Injury: Evidence in Support of Its Existence and a Review of Its Pathogenesis and Management.International journal of nephrology and renovascular disease · 2022Review
- Contrast associated nephropathy after intravenous administration: what is the magnitude of the problem?Renal failure · 2021Review
- Iodinated contrast medium: Is there a re(n)al problem? A clinical vignette-based review.Critical care (London, England) · 2020Review
- Evaluating the Association between Contrast Medium Dosage and Acute Kidney Injury in Transcatheter Aortic Valve Replacement Using Different Predictive Models.Journal of clinical medicine · 2020Article
- Acute Renal Failure/Acute Kidney Injury (AKI) Associated with Endovascular Procedures.Diagnostics (Basel, Switzerland) · 2020Review
- Save the Brain First: CTA and Mechanical Thrombectomy in Patients at Risk for Contrast-Induced Nephropathy.AJNR. American journal of neuroradiology · 2020Article
- Updated guidelines for intravenous contrast use for CT and MRI.Emergency radiology · 2020Review
- Contrast-Induced Acute Kidney Injury in Radiologic Management of Acute Ischemic Stroke in the Emergency Setting.AJNR. American journal of neuroradiology · 2020Observational
- Guideline on the use of iodinated contrast media in patients with kidney disease 2018.Japanese journal of radiology · 2020Article
- Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke.Stroke research and treatment · 2020Article
- Multimodal CT in Acute Stroke.Current neurology and neuroscience reports · 2019Review
- Risk of Acute Kidney Injury with Consecutive, Multidose Use of Iodinated Contrast in Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
background and purposeConcerns have recently grown regarding the safety of iodinated contrast agents used for CTA and CTP imaging. We tested whether the incidence of AN, defined by a >or=25% increase in the post-contrast scan creatinine level, was higher among patients with ischemic stroke who underwent a functional contrast-enhanced CT protocol compared with those who had no iodinated contrast administration. MATERIALS AND
methodsThe contrast-exposed group consisted of 575 patients with acute ischemic stroke who underwent CTA (n = 313), CTA/CTP (n = 224), or CTA/CTP followed by conventional angiography (n = 38) within 24 hours of stroke onset and were consecutively enrolled in a prospective cohort study. The nonexposed group consisted of 343 patients with ischemic stroke, consecutively admitted to the same institution, who did not receive iodinated contrast material. Patients were stratified by baseline eGFR. In the primary analysis, the Fisher exact test was used to compare the incidence of AN between the contrast-exposed and the nonexposed patients at 24, 48, and 72 hours and on a cumulative basis. A secondary analysis compared the incidence of AN in patients who underwent conventional angiography following CTA/CTP versus patients who underwent CTA/CTP only.
resultsThe incidence of AN was 5% in the exposed and 10% in the nonexposed group (P = .003). Patients who underwent conventional angiography after contrast CT were at no greater risk of AN than patients who underwent CTA/CTP alone (26 patients, 5%; and 2 patients, 5%, respectively; P = .7).
conclusionsAdministration of a contrast-enhanced CT protocol involving CTA/CTP and conventional angiography in selected patients does not appear to increase the incidence of CIN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.