ArticleBiomaterials2010
Transient in vitro epigenetic reprogramming of skin fibroblasts into multipotent cells.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- TGFβ inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.Scientific reports · 2023Article
- LncRNA Osilr9 coordinates promoter DNA demethylation and the intrachromosomal loop structure required for maintaining stem cell pluripotency.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network.Genome biology · 2021Article
- Novel cell sources for bone regeneration.MedComm · 2021Review
- Oplr16 serves as a novel chromatin factor to control stem cell fate by modulating pluripotency-specific chromosomal looping and TET2-mediated DNA demethylation.Nucleic acids research · 2020Article
- CDKN2B upregulation prevents teratoma formation in multipotent fibromodulin-reprogrammed cells.The Journal of clinical investigation · 2019Article
- Combined RNA-seq and RAT-seq mapping of long noncoding RNAs in pluripotent reprogramming.Scientific data · 2018Article
- Fibromodulin reprogrammed cells: A novel cell source for bone regeneration.Biomaterials · 2016Article
- Cellular reprogramming in farm animals: an overview of iPSC generation in the mammalian farm animal species.Journal of animal science and biotechnology · 2016Review
- Brief azacytidine step allows the conversion of suspension human fibroblasts into neural progenitor-like cells.Cell journal · 2015Article
- Generation of pluripotent stem cells without the use of genetic material.Laboratory investigation; a journal of technical methods and pathology · 2015Review
- Reprogrammed peripheral blood mononuclear cells are able to survive longer in irradiated female mice.Molecular biotechnology · 2013Article
- Could cancer initiate from bone marrow progenitors?Iranian journal of cancer prevention · 2013Review
- Induced autologous stem cell transplantation for treatment of rabbit renal interstitial fibrosis.PloS one · 2013Article
- Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway.Biomaterials · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Multipotent stem cells have the potential to establish a new field of promising regenerative medicine to treat tissue damage, genetic disorders, and degenerative diseases. However, limited resource of stem cells has turned to be an evitable obstacle in clinical applications. We utilized a simple in vitro epigenetic reprogramming approach to convert skin fibroblasts into multipotent cells. After transient reprogramming, stem cell markers, including Oct4 and Nanog, became activated in the treated cells. The reprogrammed cells were multipotent as demonstrated by their ability to differentiate into a variety of cells and to form teratomas. Genomic imprinting of insulin-like growth factor II (Igf2) and H19 was not affected by this short period of cell reprogramming. This study may provide an alternative strategy to efficiently generate patient-specific stem cells for basic and clinical research, solving major hurdles of virally-induced pluripotent stem (iPS) cells that entail the potential risks of mutation, gene instability, and malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.