ArticleFree radical biology & medicine2010
Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway.
Article in Free radical biology & medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration.Free radical biology & medicine · 2023Article
- Platelet Activation Favours NOX2-Mediated Muscle Damage in Elite Athletes: The Role of Cocoa-Derived Polyphenols.Nutrients · 2022Article
- Reactive Oxygen Species in Venous Thrombosis.International journal of molecular sciences · 2020Review
- The phagocyte NOX2 NADPH oxidase in microbial killing and cell signaling.Current opinion in immunology · 2019Review
- Dexmedetomidine Protects Against Chemical Hypoxia-Induced Neurotoxicity in Differentiated PC12 Cells Via Inhibition of NADPH Oxidase 2-Mediated Oxidative Stress.Neurotoxicity research · 2019Article
- Olfactomedin 4 contributes to hydrogen peroxide-induced NADPH oxidase activation and apoptosis in mouse neutrophils.American journal of physiology. Cell physiology · 2018Article
- Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability.The Journal of biological chemistry · 2017Article
- The Pathophysiological Role of NOX2 in Hypertension and Organ Damage.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Review
- Diabetes and Kidney Disease: Role of Oxidative Stress.Antioxidants & redox signaling · 2016Review
- Propofol Protects Against H2O2-Induced Oxidative Injury in Differentiated PC12 Cells via Inhibition of Ca(2+)-Dependent NADPH Oxidase.Cellular and molecular neurobiology · 2016Article
- Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet.The Journal of biological chemistry · 2015Article
- Over-expression of catalase in myeloid cells confers acute protection following myocardial infarction.International journal of molecular sciences · 2014Article
- Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells.American journal of physiology. Renal physiology · 2013Article
- Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression.Molecular and cellular biology · 2013Article
- PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.Immunopharmacology and immunotoxicology · 2013Article
- Mechanisms of Nrf2 protection in astrocytes as identified by quantitative proteomics and siRNA screening.PloS one · 2013Article
- Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase.PloS one · 2013Article
- Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration.Free radical biology & medicine · 2012Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The importance of H(2)O(2) as a cellular signaling molecule has been demonstrated in a number of cell types and pathways. Here we explore a positive feedback mechanism of H(2)O(2)-mediated regulation of the phagocyte respiratory burst NADPH oxidase (NOX2). H(2)O(2) induced a dose-dependent stimulation of superoxide production in human neutrophils, as well as in K562 leukemia cells overexpressing NOX2 system components. Stimulation was abrogated by the addition of catalase, the extracellular Ca(2+) chelator BAPTA, the T-type Ca(2+) channel inhibitor mibefradil, the PKCdelta inhibitor rottlerin, or the c-Abl nonreceptor tyrosine kinase inhibitor imatinib mesylate or by overexpression of a dominant-negative form of c-Abl. H(2)O(2) induced phosphorylation of tyrosine 311 on PKCdelta and this activating phosphorylation was blocked by treatment with rottlerin, imatinib mesylate, or BAPTA. Rac GTPase activation in response to H(2)O(2) was abrogated by BAPTA, imatinib mesylate, or rottlerin. In conclusion, H(2)O(2) stimulates NOX2-mediated superoxide generation in neutrophils and K562/NOX2 cells via a signaling pathway involving Ca(2+) influx and c-Abl tyrosine kinase acting upstream of PKCdelta. This positive feedback regulatory pathway has important implications for amplifying the innate immune response and contributing to oxidative stress in inflammatory disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.