Evidence map›Paper›PMID 20043983›Full record

Trial reportBrain, behavior, and immunity2010

Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection in addition to depressed mood.

Naomi I Eisenberger, Tristen K Inagaki, Nehjla M Mashal, Michael R Irwin

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain, behavior, and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05654441 (Low-grade Inflammatory Challenge and Social Behavior), which is not on this map. Cited by 212 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 5 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05654441 phase4completednot on this mapstarted 2022, after this paper: background citation

Low-grade Inflammatory Challenge and Social Behavior

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2023Enrolled104ConditionsPsychology, Social, Inflammation, Defeat, Social, Interaction, SocialArmsInfluenza vaccine, Placebo
3 · Its place in the literature

Who cites it

212 citing papers in PubMed, 5 syntheses or guidelines pooled it, 390 citations in OpenAlex.

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  11. A Randomized Controlled Trial of Tai Chi Chih or Health Education for Geriatric Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
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152 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, CA 90095-1563, USA. neisenbe@ucla.edu
Tristen K Inagaki
Nehjla M Mashal
Michael R Irwin
University of California, Los Angeles · USNorthwestern University · USSalk Institute for Biological Studies · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Subjective Social Isolation and Sleep Disturbances: Inflammatory Mechanisms in AgR01AG034588 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2009 to 2013
$1.9M
Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
Combinatorial Genomics in CancerR01CA116778 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2006 to 2010
$1.5M
NCI NIH HHS CA-10014152NCI NIH HHS CA-116778NCI NIH HHS R01 CA116778NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865NHLBI NIH HHS HL-079955NHLBI NIH HHS R01 HL079955NIA NIH HHS AG-026364NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIA NIH HHS R01 AG026364NIA NIH HHS R01 AG034588NIMH NIH HHS T32 MH019925NIMH NIH HHS T32-MH19925
6 · The paper itself

Abstract

Although research has established links between feelings of social isolation and inflammation, the direction of these effects is unclear. Based on the role that proinflammatory cytokines play in initiating "sickness behavior," which includes symptoms such as social withdrawal, it is possible that inflammatory processes heighten feelings of 'social disconnection.' Here, we examined whether exposure to an inflammatory challenge increased self-reported feelings of social disconnection. In addition, because both inflammatory processes and feelings of social disconnection contribute to depressive symptoms, we also explored whether increases in feelings of social disconnection played a role in the link between inflammation and depressed mood. Participants were randomly assigned to either receive endotoxin, an inflammatory challenge, or placebo. Proinflammatory cytokines (IL-6, TNF-alpha) were collected at baseline and then hourly for 6h. Participants completed self-reports of sickness symptoms ("fatigue"), social disconnection ("I feel disconnected from others"), and depressed mood ("unhappy") hourly. Results revealed that endotoxin led to significant increases (from baseline) in IL-6 and TNF-alpha levels as well as feelings of social disconnection and depressed mood. Moreover, controlling for increases in social disconnection eliminated the relationship between exposure to inflammatory challenge and depressed mood. This study demonstrates that inflammation can have social psychological consequences, which may play a role in cytokine-related depressive symptoms.

Indexed as

Interpersonal RelationsSocial BehaviorAdolescentAdultDepressionDouble-Blind MethodEndotoxinsFatigueFemaleHumansInflammationInterleukin-6MaleTumor Necrosis Factor-alphaYoung AdultEndotoxinsInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID20043983
PMCPMC2856755
OpenAlexW2161296293

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.