ArticleBiochemical and biophysical research communications2010
Sclerostin binds and regulates the activity of cysteine-rich protein 61.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- The Cellular Choreography of Osteoblast Angiotropism in Bone Development and Homeostasis.International journal of molecular sciences · 2021Review
- CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Observational
- Sclerostin inhibits osteoblast differentiation without affecting BMP2/SMAD1/5 or Wnt3a/β-catenin signaling but through activation of platelet-derived growth factor receptor signaling in vitro.BoneKEy reports · 2015Article
- Article
- Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone.Biochemical and biophysical research communications · 2014Article
- Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome.Science translational medicine · 2013Article
- Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.The Journal of biological chemistry · 2012Article
- The sclerostin-bone protein interactome.Biochemical and biophysical research communications · 2012Article
- Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice.Endocrinology · 2011Article
- Determination of serum and plasma sclerostin concentrations by enzyme-linked immunoassays.The Journal of clinical endocrinology and metabolism · 2011Article
- Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.Frontiers in bioscience (Landmark edition) · 2011Review
- The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.PloS one · 2011Article
- Sclerostin-erbB-3 interactions: modulation of erbB-3 activity by sclerostin.Biochemical and biophysical research communications · 2010Article
- CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway.The Journal of biological chemistry · 2010Article
- Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sclerostin, a secreted glycoprotein, regulates osteoblast function. Using yeast two-hybrid and direct protein interaction analyses, we demonstrate that sclerostin binds the Wnt-modulating and Wnt-modulated, extracellular matrix protein, cysteine-rich protein 61 (Cyr61, CCN1), which regulates mesenchymal stem cell proliferation and differentiation, osteoblast and osteoclast function, and angiogenesis. Sclerostin was shown to inhibit Cyr61-mediated fibroblast attachment, and Cyr61 together with sclerostin increases vascular endothelial cell migration and increases osteoblast cell division. The data show that sclerostin binds to and influences the activity of Cyr61.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.