ArticleBMC infectious diseases2009
Clinical presentation, demographics and outcome of tuberculosis (TB) in a low incidence area: a 4-year study in Geneva, Switzerland.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- Multidrug-resistant tuberculosis treatment adherence in migrants: a systematic review and meta-analysis.BMC medicine · 2018Pooled it
- Pooled it
- Prevalence and short-term outcomes of acute complications of tuberculosis: a cross-sectional, monocentre, Italian study.BMC infectious diseases · 2025Article
- Approach for tuberculosis-associated immune reconstitution inflammatory syndrome in an HIV-negative patient.BMJ case reports · 2021Article
- A 5-year experience characterizing the demographic and clinical profile and directly observed treatment short-course treatment outcome in National Tuberculosis Center of Duhok province, Iraqi Kurdistan.SAGE open medicine · 2020Article
- Treatment outcomes of extrapulmonary tuberculosis in Bahawalpur, Pakistan; a record review.Journal of pharmaceutical policy and practice · 2020Article
- Pulmonary Versus Extrapulmonary Tuberculosis Associated Factors: A Case-Case Study.Microbiology insights · 2019Article
- Evaluating the Contribution ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018Article
- Screening for tuberculosis in an urban shelter for homeless in Switzerland: a prospective study.BMC infectious diseases · 2017Article
- Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study.Journal of pharmaceutical policy and practice · 2017Article
- Assessment of the influence of direct tobacco smoke on infection and active TB management.PloS one · 2017Article
- Article
- Treatment outcome of new smear positive pulmonary tuberculosis patients in Penang, Malaysia.BMC infectious diseases · 2014Article
- Tuberculosis deaths: are we measuring accurately?Journal of pharmaceutical policy and practice · 2014Article
- Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes.PloS one · 2012Article
- Epidemiology of tuberculosis in a low-incidence Italian region with high immigration rates: differences between not Italy-born and Italy-born TB cases.BMC public health · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of tuberculosis (TB) in developed countries has decreased since the 1990s, reflecting worldwide efforts to identify and treat TB according to WHO recommendations. However TB remains an important public health problem in industrialized countries with a high proportion of cases occurring among subjects originating from high prevalence countries. The aim of this study was to describe clinical and social characteristics of patients with TB and their outcome in a low incidence area with a high immigration rate.
methodsFour-year retrospective study based on a computerized database and subsequent review of medical records of all patients with TB followed at the outpatient section of the Division of Pulmonary Diseases, Geneva University Hospital, Switzerland.
results252 patients (84% foreigners, 25% asylum seekers) aged 38 +/- 19 yrs were studied (11% co-infected with HIV). TB was intrapulmonary (TBP) in 158 cases (63%), extrapulmonary (TBE) in 137 (54%), and both in 43 cases (17%). TBP was smear (S)+/culture (C)+ in 59%, S-/C+ in 37%, S-/C- in 4%. Smoking was significantly associated with cavitary disease.Time from onset of symptoms to diagnosis was 2.1 +/- 3.1 months. Initially, 10% were asymptomatic; 35% had no general symptoms. Despite systematic sputum analysis (induced or spontaneous), TBP was confirmed only by bronchoscopy in 38 subjects (24% of TBP). Side effects requiring changes in treatment occurred in 38 cases (11%).Treatment was completed in 210 (83%) patients. In 42 cases, follow up was unsuccessful; causes were: failure (n = 2; 0.8%), defaulters (n = 8; 3%), transfer out (n = 28; 11%) and death (n = 4; 1.6%). Relapse rate was 0.24 per 100 patient-years. Considering S+ TBP only, success rate was 87%.
conclusionTB in our area is predominantly a disease of young foreign-born subjects. Smoking appears as a possible risk factor for cavitary TBP. Time to diagnosis remains long. Compliance to treatment is satisfactory. Success rate for S+ TBP is within WHO objectives.
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