ArticleThe Journal of infectious diseases2010
Induction of type 2 responses by schistosome worms during prepatent infection.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Plasmodium and intestinal parasite perturbations of the infected host's inflammatory responses: a systematic review.Parasites & vectors · 2018Pooled it
- Pooled it
- Expression of interleukin-4 in schistosomiasis is influenced by age.PLoS neglected tropical diseases · 2025Article
- Temporal modulation of gene expression in a controlledFrontiers in immunology · 2025Article
- Co-expression gene module analysis in response to attenuated cercaria vaccine reveals a critical role for NK cells in protection against Schistosoma mansoni.Parasites & vectors · 2024Article
- Article
- Individually or as a Team-The Immunological Milieu in the Lung Caused by Migrating Single-Sex or Mixed-Sex Larvae ofPathogens (Basel, Switzerland) · 2023Article
- Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.Nature communications · 2023Article
- Immunological mechanisms involved in macrophage activation and polarization in schistosomiasis.Parasitology · 2023Review
- Coinfection withJournal of tropical medicine · 2023Article
- Unisexual infection withFrontiers in immunology · 2023Article
- A one-year unisexualFrontiers in immunology · 2022Article
- Dynamics of Host Immune Response Development DuringFrontiers in immunology · 2022Article
- Schistosome immunomodulators.PLoS pathogens · 2021Review
- Immunological and Biochemical Interplay between Cytokines, Oxidative Stress and Schistosomiasis.International journal of molecular sciences · 2021Review
- Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice.Parasites & vectors · 2021Article
- Schistosomes in the Lung: Immunobiology and Opportunity.Frontiers in immunology · 2021Review
- The Genetics of Human Schistosomiasis Infection Intensity and Liver Disease: A Review.Frontiers in immunology · 2021Review
- Behind Enemy Lines: Immunomodulatory Armamentarium of the Schistosome Parasite.Frontiers in immunology · 2020Review
- A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.PLoS neglected tropical diseases · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
During natural schistosome infection, the induction of T helper type 2 (Th2) responses has been ascribed to parasite eggs, because exposure of the host to this life-cycle stage elicits a polarized Th2 response to egg antigens. In the present study, we show that schistosome worms also elicit systemic, antigen-specific type 2 responses during prepatent infection, before egg deposition begins. CD4(+) T cells producing interleukin (IL)-4 were induced by both male and female worms during single-sex infections, demonstrating that this response is independent of exposure to eggs. The Th2 response was accompanied by production of immunoglobulin E and the sensitization of circulating basophils to produce additional IL-4 in response to schistosome antigens. Together, our data show that schistosome worms establish an immunologic milieu where CD4(+) T cells and basophils are both primed to produce IL-4 before eggs are laid, suggesting that worms play a role in establishment of the Th2 response that is critical for host survival and parasite transmission.
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