ArticleEMBO molecular medicine2010
Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation.
Article in EMBO molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Myc-dependent dedifferentiation of Gata6Nature cell biology · 2023Article
- KRAS-Dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors and Perspectives of Therapy.International journal of molecular sciences · 2023Review
- Aging in the sebaceous gland.Frontiers in cell and developmental biology · 2022Review
- Article
- Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment.Cancer discovery · 2020Article
- Article
- Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.Nucleic acids research · 2017Article
- The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice.Scientific reports · 2017Article
- The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Stemness Transcriptional ProfileBioMed research international · 2017Article
- p53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin.The British journal of dermatology · 2016Article
- Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal stem cell proliferation and differentiation.Cell & bioscience · 2015Article
- BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions.Stem cell reports · 2014Article
- Keratin 76 is required for tight junction function and maintenance of the skin barrier.PLoS genetics · 2014Article
- Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.Cell reports · 2014Article
- Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers.Cell death & disease · 2014Article
- Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis.The EMBO journal · 2013Article
- c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis.Cell reports · 2013Article
- miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.The Journal of cell biology · 2012Article
- Deciphering c-MYC-regulated genes in two distinct tissues.BMC genomics · 2011Article
- Cell-extracellular matrix interactions in normal and diseased skin.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Myc is activated in many tumours, yet, paradoxically, stimulates differentiation in mammalian epidermis. To test whether the epidermis responds differently to different levels of Myc, we treated K14MycER transgenic mice with a range of concentrations of the inducing agent, 4-hydroxy-tamoxifen (4OHT). Proliferation was stimulated at all levels of Myc activity; sebocyte differentiation was stimulated at low and intermediate levels; and interfollicular epidermal differentiation at intermediate and high levels. Mutational inactivation of the Myc p21 activated kinase 2 (PAK2) phosphorylation sites increased Myc activity and further enhanced epidermal differentiation. We conclude that Myc induced differentiation acts as a fail-safe device to prevent uncontrolled proliferation and neoplastic conversion of epidermal stem cells expressing high levels of Myc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.