ArticleCurrent genetics2010
AoxA is a major peroxisomal long chain fatty acyl-CoA oxidase required for beta-oxidation in A. nidulans.
Article in Current genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- PdEch1 regulates the conidia production of Penicillium digitatum and oxidative stress tolerance.Genes & genomics · 2026Article
- Fatty acids in filamentous pathogenic fungi: Multidimensional regulation and pathogenic mechanisms.Virulence · 2025Review
- Biosynthesis of insect sex pheromone precursors via engineered β-oxidation in yeast.FEMS yeast research · 2022Article
- Characterization of Acyl-CoA Oxidases from the Lipolytic YeastJournal of microbiology and biotechnology · 2022Article
- Functional Characterization ofFrontiers in plant science · 2021Article
- Identification and Characterization ofCells · 2019Article
- Elucidating how the saprophytic fungus Aspergillus nidulans uses the plant polyester suberin as carbon source.BMC genomics · 2014Article
- Peroxisomal and mitochondrial β-oxidation pathways influence the virulence of the pathogenic fungus Cryptococcus neoformans.Eukaryotic cell · 2012Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- Wood utilization is dependent on catalase activities in the filamentous fungus Podospora anserina.PloS one · 2012Article
- Contributions of the peroxisome and β-oxidation cycle to biotin synthesis in fungi.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous fungi can use a variety of fatty acids (FA) as sole carbon and energy sources. Aspergillus nidulans has been shown to possess both peroxisomal and mitochondrial beta-oxidation pathways. In these studies, the major peroxisomal long chain fatty acyl coenzyme A oxidase AoxA was identified. AoxA was shown to be localised to peroxisomes and deletion of the aoxA gene leads to reduced growth on long chain FA, but not on short chain FA. AoxA is predicted to be part of the same peroxisomal beta-oxidation pathway as the bifunctional protein FoxA. In addition, an aoxA(p)lacZ reporter gene construct is induced by short and long chain FA and the induction is dependent on the transcriptional regulators FarA, FarB and ScfA with FarA being required for the induction by short chain as well as long chain FA and FarB and ScfA being required for induction of aoxA by short chain FA. It is proposed that there are additional peroxisomal beta-oxidation pathways in A. nidulans, which include fatty acyl-CoA dehydrogenases with a partially overlapping substrate range and include a pathway for short chain FA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.