ArticleDigestive diseases and sciences2010
Clinical significance of genotypes and precore/basal core promoter mutations in HBV related chronic liver disease patients in North India.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.Hepatology international · 2016Guideline
- Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood - Clinical, Virological and Immunological Long-Term Follow-Up.Journal of viral hepatitis · 2026Article
- Molecular analysis of HBV pre-core gene mutations in patients co-infected with HIV at a tertiary care hospital in North India.Access microbiology · 2025Article
- Diversity of HBV genotypes and their association with precore/basal core mutations among HBsAg-positive patients in Ibadan, Nigeria.Access microbiology · 2024Article
- Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity.World journal of hepatology · 2022Review
- Prevalence of Hepatitis B Virus, Genotypes, and Mutants in HBsAg-Positive Patients in Meerut, IndiaIranian biomedical journal · 2019Article
- Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India.Saudi journal of biological sciences · 2018Article
- Current Scenario of Hepatitis B and Its Treatment in India.Journal of clinical and translational hepatology · 2017Review
- Treatment strategies according to genotype for chronic hepatitis B in children.Annals of translational medicine · 2016Review
- Hepatitis B virus genotypes and variants.Cold Spring Harbor perspectives in medicine · 2015Review
- Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance.World journal of hepatology · 2015Review
- Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India.World journal of gastroenterology · 2013Article
- Hepatitis B virus genotyping: is the time ripe for routine clinical use?Journal of clinical and experimental hepatology · 2012Article
- Is there any value to hepatitis B virus genotype analysis?Current gastroenterology reports · 2012Review
- Prevalence of Genotype D and Precore/Core Promoter Mutations in Hepatitis B Virus-infected Population of North India.Journal of clinical and experimental hepatology · 2011Article
- A Narrative Review on the Specific Pattern of HBV Genotype in Bangladesh: Clinical Implications for Management.Euroasian journal of hepato-gastroenterologyReview
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeData on genotypes, basal core promoter (BCP) and precore mutants of hepatitis B virus and their association with different HBV related liver disease have been studied inadequately and are controversial. Thus, the aim of this study was to determine the incidence of BCP and precore HBV mutants and their relationship with HBV genotype and different stages of HBV related liver disease in North Indian patients.
methodsA total 273 patients with different stages of HBV related liver diseases were enrolled. Nested polymerase chain reaction (PCR) was used to amplify the BCP/PC regions. RFLP and direct sequencing were performed to validate the mutations identified in these regions. HBV genotyping was accomplished by multiplex PCR.
resultsGenotype D was the predominant genotype found in each of the various HBV related liver diseases. The BCP mutation was found significantly more often in inactive carriers and compensated cirrhosis as compared to the other groups. The BCP mutation was present in 29.1% of patients with genotype D versus 17.1% with genotype A (P = 0.001). The precore mutation was also more frequently observed with genotype D compared with genotype A (36.9 vs. 4.8%, P = 0.0007).
conclusionGenotype D is predominant in North Indian patients. The BCP and precore mutations occur in one-third of HBV positive patients in association with the genotype D. We did not find any correlation with severity of liver disease with genotypes and mutations.
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