ArticleCellular and molecular life sciences : CMLS2010
Catestatin, an endogenous chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- A small antimicrobial peptide derived from a Burkholderia bacterium exhibits a broad-spectrum and high inhibiting activities against crop diseases.Plant biotechnology journal · 2025Article
- Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis.Cellular and molecular life sciences : CMLS · 2023Review
- The Catestatin-Derived Peptides Are New Actors to Fight the Development of Oral Candidosis.International journal of molecular sciences · 2022Article
- The antimicrobial peptides secreted by the chromaffin cells of the adrenal medulla link the neuroendocrine and immune systems: From basic to clinical studies.Frontiers in immunology · 2022Review
- Article
- Cell Membrane-Interrupting Antimicrobial Peptides fromBiomolecules · 2019Article
- Molecular Design, Structural Analysis and Antifungal Activity of Derivatives of Peptide CGA-N46.Interdisciplinary sciences, computational life sciences · 2016Article
- Anti-candidal activity of a novel peptide derived from human chromogranin A and its mechanism of action againstExperimental and therapeutic medicine · 2015Article
- Antibacterial Peptide-Based Gel for Prevention of Medical Implanted-Device Infection.PloS one · 2015Article
- Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity.Malaria journal · 2011Article
- Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.Immunology · 2011Article
- Reprint of: Catestatin: a multifunctional peptide from chromogranin A.Regulatory peptides · 2010Article
- Catestatin: a multifunctional peptide from chromogranin A.Regulatory peptides · 2010Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides on the growth of Plasmodium falciparum in vitro. Catestatin inhibits growth of the chloroquine-sensitive strain of P. falciparum 3D7, exhibiting 88% inhibition at 20 microM. A similar partial inhibition of parasite growth was observed for the chloroquine-resistant strain, 7G8 (64%,) and the multidrug-resistant strain, W2 (62%). In the presence of parasite-specific lactate dehydrogenase, a specific protein-protein interaction between catestatin and plasmepsin II precursor was demonstrated. In addition, catestatin partially inhibited the parasite-specific proteases plasmepsin in vitro. A specific interaction between catestatin and plasmepsins II and IV from P. falciparum and plasmepsin IV from the three remaining species of Plasmodium known to infect man was observed, suggesting a catestatin-induced reduction in availability of nutrients for protein synthesis in the parasite.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.