Evidence map›Paper›PMID 20043145›Full record

ArticleDiabetologia2010

Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study.

S-M Ruchat, T Rankinen, S J Weisnagel, T Rice, D C Rao, R N Bergman, C Bouchard, L Pérusse

Abstract read
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In one paragraph

Article in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
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  13. Novel Genetic Variants ofFrontiers in endocrinology · 2020
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  19. Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases?International journal of molecular sciences · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

S-M RuchatDepartment of Social and Preventive Medicine, PEPS-Laval University, 2300 rue de Terrasse, Quebec, QC, Canada G1V 0A6.
T Rankinen
S J Weisnagel
T Rice
D C Rao
R N Bergman
C Bouchard
L Pérusse

Funding

HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047317 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 1992 to 2003
$1.8M
HERITAGE STUDY: GENETICS, EXERCISE AND RISK FACTORSR01HL047321 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI WILMORE, JACK H · 1992 to 2003
$108k
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047327 · NHLBI · INDIANA UNIVERSITY BLOOMINGTON · PI SKINNER, JAMES STANFORD · 1992 to 2003
$106k
HERITAGE STUDY: GENETICS, RESP. TO EXERCISE/RISK FACTORSR01HL047323 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LEON, ARTHUR S · 1992 to 2003
$100k
NHLBI NIH HHS HL-45670NHLBI NIH HHS HL-47317NHLBI NIH HHS HL-47321NHLBI NIH HHS HL-47323NHLBI NIH HHS HL-47327NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327
6 · The paper itself

Abstract

aims/hypothesisExercise training improves glucose homeostasis, but large inter-individual differences are reported, suggesting a role of genetic factors. We investigated whether variants either confirmed or newly identified as diabetes susceptibility variants through genome-wide association studies (GWAS) modulate changes in phenotypes derived from an IVGTT in response to an endurance training programme.

methodsWe analysed eight polymorphisms in seven type 2 diabetes genes (CDKAL1 rs7756992; CDKN2A and CDKN2B rs10811661 and rs564398; HHEX rs7923837; IGF2BP2 rs4402960; KCNJ11 rs5215; PPARG rs1801282; and TCF7L2 rs7903146) in a maximum of 481 sedentary, non-diabetic white individuals, who participated in a 20-week endurance training programme. Associations were tested between the variants and changes in IVGTT-derived phenotypes.

resultsThe only evidence of association with training response was found with PPARG rs1801282 (Pro12Ala). We observed that Ala carriers experienced greater increase in overall glucose tolerance (Deltaglucose disappearance index Ala/Ala 0.22 +/- 0.22, Pro/Ala 0.14 +/- 0.06, Pro/Pro 0.004 +/- 0.03; p = 0.0008), glucose effectiveness (Ala/Ala 0.28 +/- 0.41, Pro/Ala 0.44 +/- 0.14, Pro/Pro 0.09 +/- 0.06; p = 0.004), acute insulin response to glucose (Ala/Ala 64.21 +/- 37.73, Pro/Ala -11.92 +/- 40.30, Pro/Pro -46.30 +/- 14.70; p = 0.03) and disposition index (Ala/Ala 551.8 +/- 448.5, Pro/Ala 534.6 +/- 218.3, Pro/Pro -7.44 +/- 88.18; p = 0.003). CONCLUSIONS/

interpretationCompared with Pro/Pro individuals, PPARG Ala carriers experienced greater improvements in glucose and insulin metabolism in response to regular endurance training. However, we did not find evidence of association between type 2 diabetes susceptibility variants recently identified through GWAS and glucose homeostasis response to exercise. Our results extend those of previous studies showing that Ala carriers appear to be more responsive to beneficial health effects of lifestyle interventions.

Indexed as

Amino Acid SubstitutionBlood GlucoseDiabetes MellitusExerciseFamilyGene FrequencyGenes, p16Genetic VariationGenotypeGlucose IntoleranceGlucose Tolerance TestHomeostasisHumansInsulin-Like Growth Factor Binding Protein 2Life StylePolymorphism, GeneticBlood GlucoseInsulin-Like Growth Factor Binding Protein 2PPAR gammaDiabetes susceptibility genesIVGTT-derived phenotypesPolymorphismsResponse to exercise

Identifiers

PMID20043145
PMCPMC2840709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.