ArticleActa biochimica et biophysica Sinica2010
Evaluation of Ca2+ permeability of nicotinic acetylcholine receptors in hypothalamic histaminergic neurons.
Article in Acta biochimica et biophysica Sinica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Allosterically PotentiatedMolecular pharmacology · 2020Article
- Another interpretation of the Goldman-Hodgkin-Katz equation based on Ling's adsorption theory.European biophysics journal : EBJ · 2018Article
- Evidence for the exclusive expression of functional homomeric α7 nAChRs in hypothalamic histaminergic tuberomammillary neurons in rats.Neuroscience letters · 2014Article
- α7nAchR/NMDAR coupling affects NMDAR function and object recognition.Molecular brain · 2013Article
- The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels.European journal of pharmacology · 2013Article
- A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia.British journal of pharmacology · 2013Article
- Article
- Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.Neuropharmacology · 2012Article
- α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.Advances in experimental medicine and biology · 2012Review
- Mechanisms of facilitation of synaptic glutamate release by nicotinic agonists in the nucleus of the solitary tract.American journal of physiology. Cell physiology · 2011Article
- Article
- Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].The Journal of pharmacology and experimental therapeutics · 2010Article
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1 author at 1 institution in 1 country.
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Abstract
Hypothalamic histaminergic tuberomammillary (TM) neurons express nicotinic acetylcholine receptors (nAChRs) with kinetic and pharmacological properties resembling those of highly Ca(2+) permeable alpha7 nAChRs. However, the Ca(2+) permeability of TM nAChR channels has not been determined. To directly evaluate the Ca(2+) permeability of TM nAChRs, patch-clamp recordings were conducted using non-cultured acutely dissociated TM neurons and external solutions containing low (2 mM) and high (20 mM) concentrations of Ca(2+). A shift in the reversal potentials was determined from the current-voltage relationships and the permeability ratio, P(Ca)/P(Na), was estimated within the Goldman-Hodgkin-Katz constant field approximation. TM nAChRs were found to be highly Ca(2+) permeable with the permeability ratio, P(Ca)/P(Na)(nAChR) being approximately 5.9 and the fractional Ca(2+) current, P(f)(nAChR) being approximately 10.1% at -60 mV. As a positive control for the applied methods and analysis, the permeability ratio, P(Ca)/P(Na)(NMDAR) being approximately 8.3 and the fractional Ca(2+) current, P(f)(NMDAR) being approximately 13.6% at -60 mV for NMDA receptors were determined using non-cultured acutely dissociated hippocampal pyramidal neurons and found similar to previously reported values. Therefore, these results demonstrate that native TM nAChRs are highly Ca(2+) permeable, but approximately 1.4 fold less permeable to Ca(2+) than native hippocampal pyramidal NMDA receptors.
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