ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The influence of fear on risk taking: a meta-analysis.Cognition & emotion · 2020Pooled it
- A Study of Candidate Genes Associated with Suicide Attempts in the Kazakh Population in Astana, Kazakhstan.International journal of molecular sciences · 2026Article
- Quantitative behavioral genetic and molecular genetic foundations of the approach and avoidance strategies.Current psychology (New Brunswick, N.J.) · 2022Article
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits.Brain structure & function · 2016Article
- Temporal discounting in major depressive disorder.Psychological medicine · 2014Article
- Genetics of impulse control disorders in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
- Sensation-seeking genes and physical activity in youth.Genes, brain, and behavior · 2013Article
- Genetics of impulsive behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.Journal of genetic syndromes & gene therapy · 2012Article
- Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Review
- Article
- Epigenetics in Developmental Disorder: ADHD and Endophenotypes.Journal of genetic syndromes & gene therapy · 2011Article
- Serotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making.Frontiers in genetics · 2011Article
- Rodent versions of the iowa gambling task: opportunities and challenges for the understanding of decision-making.Frontiers in neuroscience · 2011Article
- The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Patrimony and the evolution of risk-taking.PloS one · 2010Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Decision making, choosing the best option from the possible outcomes, is impaired in many psychiatric conditions including affective disorders. We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. A population cohort (N=1035) completed a paper-and-pencil gambling task, filled out personality and symptom questionnaires and gave consent for the use of their DNA in a genetic association study. A subgroup of subjects (N=69) also completed a computer version of the task. The gambling task was designed to estimate an individual's tendency to take a risk when choosing between a smaller but more certain 'win' and a larger, less probable one. We genotyped seven haplotype tagging SNPs in the TPH2 gene, and previously reported functional polymorphisms from the other genes (rs1800532, 5HTTLPR, and rs6295). Carriers of the more prevalent TPH2 haplotype, which was previously associated with less active enzyme variant, showed reduced risk taking on both tasks compared with subjects not carrying the common haplotype. The effect of TPH2 haplotypes on risk-taking was independent of current depression and anxiety symptoms, neuroticism and impulsiveness scores. We did not find an association between functional polymorphisms in the TPH1, SLC6A4, HTR1A genes and risk-taking behavior. In conclusion, our study demonstrates the role of the TPH2 gene and the serotonin system in risk taking and suggests that TPH2 gene may contribute to the expression of psychiatric phenotypes through altered decision making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.