ArticleAIDS (London, England)2010
Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples.
Article in AIDS (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Association between male circumcision and women's biomedical health outcomes: a systematic review.The Lancet. Global health · 2017Pooled it
- Circumcision Status and Risk of HIV Acquisition during Heterosexual Intercourse for Both Males and Females: A Meta-Analysis.PloS one · 2015Pooled it
- Impact of viral load and the duration of primary infection on HIV transmission: systematic review and meta-analysis.AIDS (London, England) · 2014Pooled it
- Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples.The Cochrane database of systematic reviews · 2013Pooled it
- Will circumcision provide even more protection from HIV to women and men? New estimates of the population impact of circumcision interventions.Sexually transmitted infections · 2011Pooled it
- HIV shedding from male circumcision wounds in HIV-infected men: a prospective cohort study.PLoS medicine · 2015Trial
- Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters.AIDS research and human retroviruses · 2013Trial
- Infant Circumcision for Sexually Transmitted Infection Risk Reduction Globally.Global health, science and practice · 2022Article
- Factors Influencing the Uptake of Voluntary Medical Male Circumcision Among Boda-Boda Riders Aged 18-49 Years in Hoima, Western Uganda.HIV/AIDS (Auckland, N.Z.) · 2022Article
- High HIV prevalence and associated factors in Lesotho: Results from a population-based survey.PloS one · 2022Article
- Immune parameters of HIV susceptibility in the female genital tract before and after penile-vaginal sex.Communications medicine · 2022Article
- Socio-economic and demographic factors associated with never having tested for HIV among sexually active men across the four administrative regions of Uganda.BMC public health · 2021Article
- The Impact of Male Partner Circumcision on Women's Health Outcomes.AIDS education and prevention : official publication of the International Society for AIDS Education · 2020Article
- Prevalence and determinants of recent HIV testing among older persons in rural Uganda: a cross-sectional study.BMC public health · 2020Article
- Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?Frontiers in public health · 2019Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Higher prevalence of viral control in HIV-1-infected women in serodiscordant relationships.PloS one · 2018Article
- Article
- Women's Perceptions and Misperceptions of Male Circumcision: A Mixed Methods Study in Zambia.PloS one · 2016Article
- Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
Abstract
objectiveMale circumcision reduces female-to-male HIV-1 transmission risk by approximately 60%. Data assessing the effect of circumcision on male-to-female HIV-1 transmission are conflicting, with one observational study among HIV-1-serodiscordant couples showing reduced transmission but a randomized trial suggesting no short-term benefit of circumcision. DESIGN/
methodsData collected as part of a prospective study among African HIV-1-serodiscordant couples were analyzed for the relationship between circumcision status of HIV-1-seropositive men and risk of HIV-1 acquisition among their female partners. Circumcision status was determined by physical examination. Cox proportional hazards analysis was used.
resultsA total of 1096 HIV-1-serodiscordant couples in which the male partner was HIV-1-infected were followed for a median of 18 months; 374 (34%) male partners were circumcised. Sixty-four female partners seroconverted to HIV-1 (incidence 3.8 per 100 person-years). Circumcision of the male partner was associated with a nonstatistically significant approximately 40% lower risk of HIV-1 acquisition by the female partner (hazard ratio 0.62, 95% confidence interval 0.35-1.10, P = 0.10). The magnitude of this effect was similar when restricted to the subset of HIV-1 transmission events confirmed by viral sequencing to have occurred within the partnership (n = 50, hazard ratio 0.57, P = 0.11), after adjustment for male partner plasma HIV-1 concentrations (hazard ratio 0.60, P = 0.13), and when excluding follow-up time for male partners who initiated antiretroviral therapy (hazard ratio 0.53, P = 0.07).
conclusionAmong HIV-1-serodiscordant couples in which the HIV-1-seropositive partner was male, we observed no increased risk and potentially decreased risk from circumcision on male-to-female transmission of HIV-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.