ArticleJournal of dental research2010
The amelogenin C-terminus is required for enamel development.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Serine-16 Phosphorylation, C-Terminal Truncation, and Ion-Specific Interactions Coordinate Amelogenin Nanoribbon Formation.Calcified tissue international · 2026Article
- CaAm-P19: a novel amelogenin-derived peptide for enamel remineralization.Regenerative biomaterials · 2026Article
- Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice.Journal of structural biology · 2022Article
- Mechanisms of Enamel Mineralization Guided by Amelogenin Nanoribbons.Journal of dental research · 2021Review
- A N-Terminus Domain Determines Amelogenin's Stability to Guide the Development of Mouse Enamel Matrix.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Biomimetic mineralisation systems for in situ enamel restoration inspired by amelogenesis.Journal of materials science. Materials in medicine · 2021Review
- Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor.The Journal of biological chemistry · 2020Article
- Phosphorylated and Non-phosphorylated Leucine Rich Amelogenin Peptide Differentially Affect Ameloblast Mineralization.Frontiers in physiology · 2018Article
- Dose-Dependent Rescue of KO Amelogenin Enamel by TransgenesFrontiers in physiology · 2017Article
- Posttranslational Amelogenin Processing and Changes in Matrix Assembly during Enamel Development.Frontiers in physiology · 2017Article
- Analysis of enamel development using murine model systems: approaches and limitations.Frontiers in physiology · 2014Review
- The expanded amelogenin polyproline region preferentially binds to apatite versus carbonate and promotes apatite crystal elongation.Frontiers in physiology · 2014Article
- M180 amelogenin processed by MMP20 is sufficient for decussating murine enamel.Journal of dental research · 2013Article
- Ameloblasts require active RhoA to generate normal dental enamel.European journal of oral sciences · 2013Article
- CryoTEM study of effects of phosphorylation on the hierarchical assembly of porcine amelogenin and its regulation of mineralization in vitro.Journal of structural biology · 2013Article
- Mouse genetic background influences the dental phenotype.Cells, tissues, organs · 2013Article
- Amelogenin processing by MMP-20 prevents protein occlusion inside calcite crystals.Crystal growth & design · 2012Article
- Binding of amelogenin to MMP-9 and their co-expression in developing mouse teeth.Journal of molecular histology · 2012Article
- Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides.International journal of oral science · 2012Article
- Protein-mediated enamel mineralization.Frontiers in bioscience (Landmark edition) · 2012Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The abundant amelogenin proteins are responsible for generating proper enamel thickness and structure, and most amelogenins include a conserved hydrophilic C-terminus. To evaluate the importance of the C-terminus, we generated transgenic mice that express an amelogenin lacking the C-terminal 13 amino acids (CTRNC). MicroCT analysis of TgCTRNC29 teeth (low transgene number) indicated that molar enamel density was similar to that of wild-type mice, but TgCTRNC18 molar enamel (high transgene number) was deficient, indicating that extra transgene copies were associated with a more severe phenotype. When amelogenin-null (KO) and TgCTRNC transgenic mice were mated, density and volume of molar enamel from TgCTRNCKO offspring were not different from those of KO mice, indicating that neither TgCTRNC18 nor TgCTRNC29 rescued enamel's physical characteristics. Because transgenic full-length amelogenin partially rescues both density and volume of KO molar enamel, it was concluded that the amelogenin C-terminus is essential for proper enamel density, volume, and organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.