ArticleJournal of dental research2010
Alteration of PTGS2 promoter methylation in chronic periodontitis.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Epigenetics and periodontics: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2019Pooled it
- The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis.Clinical and experimental dental research · 2026Review
- DNA Methylation of COX-2, IFN-γ, TNF-α, and LINE-1 in Clinically Stable Periodontal Tissues Following Periodontal Therapy.Clinical and experimental dental research · 2025Article
- Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity.Journal of advanced research · 2025Article
- Curcumin alleviates LPS-induced WI-38 cell inflammation injury by regulating PTGS2 expression.Hereditas · 2025Article
- Can social adversity alter the epigenome, trigger oral disease, and affect future generations?Irish journal of medical science · 2024Review
- Based on network pharmacology and molecular docking to explore the potential mechanism of shikonin in periodontitis.BMC oral health · 2024Article
- RUNX1-induced upregulation of PTGS2 enhances cell growth, migration and invasion in colorectal cancer cells.Scientific reports · 2024Article
- AmSystems · 2024Article
- The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells.Cells · 2024Review
- Methylome-wide analysis in systemic microbial-induced experimental periodontal disease in mice with different susceptibility.Frontiers in cellular and infection microbiology · 2024Article
- The Potential Role of Epigenetic Modifications on Different Facets in the Periodontal Pathogenesis.Genes · 2023Review
- DNA methylation changes underlie the long-term association between periodontitis and atherosclerotic cardiovascular disease.Frontiers in cardiovascular medicine · 2023Article
- The Relevance of DNA Methylation and Histone Modification in Periodontitis: A Scoping Review.Cells · 2022Article
- Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring.International journal of molecular sciences · 2022Review
- Emerging role of epigenetic regulations in periodontitis: a literature review.American journal of translational research · 2022Review
- Impaired function of epithelial plakophilin-2 is associated with periodontal disease.Journal of periodontal research · 2021Article
- Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases.Diseases (Basel, Switzerland) · 2021Review
- Current advances of epigenetics in periodontology from ENCODE project: a review and future perspectives.Clinical epigenetics · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Levels of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in actively progressing periodontal lesions, but decrease in chronic disease. We hypothesized that chronic inflammation is associated with altered DNA methylation levels within the PTGS2 promoter, with effects on COX-2 mRNA expression. PTGS2 promoter methylation levels from periodontally inflamed gingival biopsies showed a 5.06-fold increase as compared with non-inflamed samples (p = 0.03), and the odds of methylation in a CpG site in the inflamed gingival group is 4.46 times higher than in the same site in the non-inflamed group (p = 0.016). The level of methylation at -458 bp was inversely associated with transcriptional levels of PTGS2 (RT-PCR) (p = 0.01). Analysis of the data suggests that, in chronically inflamed tissues, there is a hypermethylation pattern of the PTGS2 promoter in association with a lower level of PTGS2 transcription, consistent with a dampening of COX-2 expression in chronic periodontitis. These findings suggest that the chronic persistence of the biofilm and inflammation may be associated with epigenetic changes in local tissues at the biofilm-gingival interface.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.