ArticleJournal of dental research2010
Hyper-responsive phenotype in localized aggressive periodontitis.
Article in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01330719 (Mechanisms and Treatment Response of Aggressive Periodontitis in Children), which is not on this map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms and Treatment Response of Aggressive Periodontitis in Children: Aberrant Immunological Phenotypes/Functions in the Progression of AgP
Who cites it
46 citing papers in PubMed.
- Adjunctive effect of gaseous ozone on inflammatory biomarkers and microbial profile in grade C molar-incisor pattern periodontitis: a randomized split-mouth placebo-controlled clinical trial.BMC oral health · 2026Trial
- Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis.Journal of periodontology · 2017Trial
- Epigenetic regulation of inflammation in localized aggressive periodontitis.Clinical epigenetics · 2017Trial
- Localized aggressive periodontitis treatment response in primary and permanent dentitions.Journal of periodontology · 2014Trial
- Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.Journal of periodontology · 2013Trial
- LPS-induced inflammatory response after therapy of aggressive periodontitis.Journal of dental research · 2013Trial
- Local inflammatory markers and systemic endotoxin in aggressive periodontitis.Journal of dental research · 2011Trial
- Grade C molar-incisor pattern periodontitis classification and its challenges.Journal of periodontology · 2026Review
- Impact of Aggregatibacter actinomycetemcomitans on inflammasome regulation and epigenetic changes in grade C periodontitis.Clinical oral investigations · 2026Article
- The interrelationship between periodontal disease and systemic health.British dental journal · 2025Review
- Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?Pathogens (Basel, Switzerland) · 2024Review
- Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals.Journal of periodontology · 2024Article
- Impact of Periodontitis on Endothelial Risk Dysfunction and Oxidative Stress Improvement in Patients with Cardiovascular Disease.Journal of clinical medicine · 2024Review
- A Modern Approach to Treat Molar/Incisor Pattern Periodontitis-Review.Journal of clinical medicine · 2023Review
- Impact of Treatment on Host Responses in Young Individuals with Periodontitis.Journal of dental research · 2023Review
- Remembering St. Louis individual-structural violence and acute bacterial infections in a historical anatomical collection.Communications biology · 2022Article
- Gender differences in immunological response of African-American juveniles with Grade C molar incisor pattern periodontitis.Journal of periodontology · 2022Article
- Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation.Journal of clinical periodontology · 2021Article
- The role of inflammation and genetics in periodontal disease.Periodontology 2000 · 2020Review
- Association of P2RX7 functional variants with localized aggressive periodontitis.Journal of periodontal research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The 'hyper-responsive' trait is an increased inflammatory response upon stimulation of innate immune receptors. Our objective was to determine if a hyper-reactive trait is present in a cohort diagnosed with aggressive periodontitis (LAgP). Peripheral blood was collected from 30 LAgP, 10 healthy unrelated, and 10 healthy sibling participants and stimulated with lipopolysaccharide (LPS) from E. coli and P. gingivalis. Cyto/chemokine response profiles were evaluated and analyzed by ANOVA. Elevated levels of pro-inflammatory cyto/chemokines were detected in E. coli and P. gingivalis LPS-stimulated LAgP cultures when compared with those of healthy unrelated control individuals. Periodontally healthy siblings presented with attenuated hyper-inflammatory cyto/chemokine profiles. Regression analysis demonstrated the hyper-reactive trait to be concomitant expression of pro-inflammatory cyto/chemokines and an absence of anti-inflammatory mediator expression. Our findings demonstrate hyper-responsive trait in a LAgP cohort, along with an attenuated hyper-responsiveness in healthy siblings, which can be induced in response to multiple TLR ligations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.