ArticleThe American journal of pathology2010
High-resolution ultrasound imaging: a novel technique for the noninvasive in vivo analysis of endometriotic lesion and cyst formation in small animal models.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Burrowing behavior is a potential non-invasive proxy for lesion development in a syngeneic murine model of endometriosis.BMC women's health · 2025Article
- Ultrasound imaging-guided protocol for monitoring tumor growth in orthotopic rat model of hepatocellular carcinoma.World journal of hepatology · 2025Article
- Using Optical Coherence Tomography in Plant Biology Research: Review and Prospects.Sensors (Basel, Switzerland) · 2025Review
- Induction and characterization of a rat model of endometriosis.Scientific reports · 2024Article
- Adverse Effects Associated with Dermal Filler Treatments: Part II Vascular Complication.Diagnostics (Basel, Switzerland) · 2024Review
- The Presence of Pre-Existing Endometriotic Lesions Promotes the Growth of New Lesions in the Peritoneal Cavity.International journal of molecular sciences · 2023Article
- Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation.Nutrients · 2022Article
- A Mouse Model of Endometriosis with Nanoparticle Labeling for In Vivo Photoacoustic Imaging.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- The ischemic time window of ectopic endometrial tissue crucially determines its ability to develop into endometriotic lesions.Scientific reports · 2022Article
- Antibiotic Therapy and Vaginal Microbiota Transplantation Reduce Endometriosis Disease Progression in Female MiceFrontiers in medicine · 2022Article
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice.Frontiers in physiology · 2021Article
- Endometriosis in the Mouse: Challenges and Progress Toward a 'Best Fit' Murine Model.Frontiers in physiology · 2021Review
- Inhibition of erythropoietin-producing hepatoma receptor B4 (EphB4) signalling suppresses the vascularisation and growth of endometriotic lesions.British journal of pharmacology · 2020Article
- Adding a dimension to cell fate.Animal reproduction · 2020Article
- Effect of the estrus cycle stage on the establishment of murine endometriosis lesions.International journal of reproductive biomedicine · 2018Article
- Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions.British journal of pharmacology · 2017Article
- Quantitative volumetric imaging of normal, neoplastic and hyperplastic mouse prostate using ultrasound.BMC urology · 2015Article
- Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.Biology of reproduction · 2015Article
- The phosphodiesterase 3 inhibitor cilostazol does not stimulate growth of colorectal liver metastases after major hepatectomy.Clinical & experimental metastasis · 2014Article
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8 authors.
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Abstract
Endometriosis, the presence of endometrial tissue at ectopic sites, is a highly prevalent gynecological disease severely affecting a patient's quality of life. To analyze the mechanisms involved in the disease and to identify new molecular targets for effective therapies, small animal models are an important approach. Herein, we report the first use of high-resolution ultrasound imaging for the in vivo analysis of intraperitoneal endometriotic lesions in mice. This noninvasive technology allows for the repetitive quantitative analysis of growth, cyst development, and adhesion formation of endometriotic lesions with a low intra- and interobserver variability. Moreover, it enables one to easily differentiate between endometrial cysts and stroma. Accordingly, volume measurements of both endometrial cysts and stroma indicated that the initial establishment of endometriotic lesions is associated with enhanced cellular proliferation, followed by a phase of increased secretory activity of endometrial glands. Results of ultrasound analysis correlated well with measurements of lesion volumes by caliper and histology. Importantly, ultrasound imaging could be performed repetitively and noninvasively and reflected best the in vivo situation. The technique could further be demonstrated to successfully monitor the significant inhibition of growth of endometriotic lesions after specific estrogen receptor destabilizator treatment. Thus, high-resolution ultrasound imaging represents an important tool for future preclinical small animal studies, which address the pathophysiology of endometriosis and the development of new treatment strategies.
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