ArticleInvestigative ophthalmology & visual science2010
Muscarinic acetylcholine receptor localization and activation effects on ganglion response properties.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Temporal integration of light flashes by the human circadian system.The Journal of clinical investigation · 2016Trial
- Long-distance object motion evokes direction selectivity in retinal neurons through nicotinic receptors in bipolar cells.Journal of neurophysiology · 2026Article
- Topical review: Potential mechanisms of atropine for myopia control.Optometry and vision science : official publication of the American Academy of Optometry · 2025Review
- Starburst amacrine cells amplify optogenetic visual restoration through gap junctions.Molecular therapy. Methods & clinical development · 2023Article
- Clinically relevant small-molecule promotes nerve repair and visual function recovery.NPJ Regenerative medicine · 2022Article
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- Muscarinic Acetylcholine Receptors in the Retina-Therapeutic Implications.International journal of molecular sciences · 2021Review
- Huperzine A lowers intraocular pressure via the M3 mAChR and provides retinal neuroprotection via the M1 mAChR: a promising agent for the treatment of glaucoma.Annals of translational medicine · 2021Article
- The Effect of Low-Dose Atropine on Alpha Ganglion Cell Signaling in the Mouse Retina.Frontiers in cellular neuroscience · 2021Article
- Bipolar Cell Type-Specific Expression and Conductance of Alpha-7 Nicotinic Acetylcholine Receptors in the Mouse Retina.Investigative ophthalmology & visual science · 2019Article
- Synergistic regulation mechanism of iperoxo and LY2119620 for muscarinic acetylcholine M2 receptor.RSC advances · 2018Article
- Retinal changes in the Tg-SwDI mouse model of Alzheimer's disease.Neuroscience · 2017Article
- Opposing effects of atropine and timolol on the color and luminance emmetropization mechanisms in chicks.Vision research · 2016Article
- IL-4 Induces Cholinergic Differentiation of Retinal Cells In Vitro.Cellular and molecular neurobiology · 2015Article
- Effect of the M1 Muscarinic Acetylcholine Receptor on Retinal Neuron Number Studied with Gene-Targeted Mice.Journal of molecular neuroscience : MN · 2015Article
- Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.Frontiers in cellular neuroscience · 2015Article
- Nicotinic and muscarinic acetylcholine receptors shape ganglion cell response properties.Journal of neurophysiology · 2015Article
- Characterization of ex vivo cultured neuronal- and glial- like cells from human idiopathic epiretinal membranes.BMC ophthalmology · 2014Article
- Pharmacologically stimulated pupil and accommodative changes in Guinea pigs.Investigative ophthalmology & visual science · 2014Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe activation and blockade of muscarinic acetylcholine receptors (mAChRs) affects retinal ganglion cell light responses and firing rates. This study was undertaken to identify the full complement of mAChRs expressed in the rabbit retina and to assess mAChR distribution and the functional effects of mAChR activation and blockade on retinal response properties.
methodsRT-PCR, Western blot analysis, and immunohistochemistry were used to identify the complement and distribution of mAChRs in the rabbit retina. Extracellular electrophysiology was used to determine the effects of the activation or blockade of mAChRs on ganglion cell response properties.
resultsRT-PCR of whole neural retina resulted in the amplification of mRNA transcripts for the m1 to m5 mAChR subtypes. Western blot and immunohistochemical analyses confirmed that all five mAChR subtypes were expressed by subpopulations of bipolar, amacrine, and ganglion cells in the rabbit retina, including subsets of cells in cholinergic and glycinergic circuits. Nonspecific muscarinic activation and blockade resulted in the class-specific modulation of maintained ganglion cell firing rates and light responses.
conclusionsThe expression of mAChR subtypes on subsets of bipolar, amacrine, and ganglion cells provides a substrate for both enhancement and suppression of retinal responses via activation by cholinergic agents. Thus, the muscarinic cholinergic system in the retina may contribute to the modulation of complex stimuli. Understanding the distribution and function of mAChRs in the retina has the potential to provide important insights into the visual changes that are caused by decreased ACh in the retinas of Alzheimer's patients and the potential visual effects of anticholinergic treatments for ocular diseases.
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