ArticleClinical and vaccine immunology : CVI2010
Specific IgG responses to recombinant antigen B and em18 in cystic and alveolar echinococcosis in china.
Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Antigen discovery by bioinformatics analysis and peptide microarray for the diagnosis of cystic echinococcosis.PLoS neglected tropical diseases · 2023Article
- Species specificity preliminary evaluation of an IL-4-based test for the differential diagnosis of human echinococcosis.Parasite immunology · 2020Article
- Diagnostic and follow-up performance of serological tests for different forms/courses of alveolar echinococcosis.Food and waterborne parasitology · 2019Article
- Echinococcosis: Advances in the 21st Century.Clinical microbiology reviews · 2019Review
- Expansion of a highly sensitive and specific ELISA test for diagnosis of hydatidosis using recombinant EgB8/2 protein.Iranian journal of basic medical sciences · 2019Article
- Evaluation of the recombinant antigens B2t and 2B2t, compared with hydatid fluid, in IgG-ELISA and immunostrips for the diagnosis and follow up of CE patients.PLoS neglected tropical diseases · 2018Article
- Ultrasound and Cystic Echinococcosis.Ultrasound international open · 2018Review
- Field evaluation of an immunochromatographic test for diagnosis of cystic and alveolar echinococcosis.Parasites & vectors · 2018Article
- Factors Influencing the Serological Response in Hepatic Echinococcus granulosus Infection.The American journal of tropical medicine and hygiene · 2016Article
- Evaluation of a New Immunochromatographic Test Using Recombinant Antigen B8/1 for Diagnosis of Cystic Echinococcosis.Journal of clinical microbiology · 2015Article
- Evaluation of immunochromatographic test for the detection of antibodies against Echinococcosis granulosus.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Serological Diagnosis and Follow-Up of Human Cystic Echinococcosis: A New Hope for the Future?BioMed research international · 2015Review
- Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors.PLoS neglected tropical diseases · 2014Article
- Article
- Differential diagnosis of cystic and alveolar echinococcosis using an immunochromatographic test based on the detection of specific antibodies.Parasitology research · 2013Article
- Serological diagnosis of echinococcosis: the diagnostic potential of native antigens.Infection · 2012Article
- Improved serodiagnosis of cystic echinococcosis using the new recombinant 2B2t antigen.PLoS neglected tropical diseases · 2012Article
- Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China.PLoS neglected tropical diseases · 2011Article
- A case of pulmonary and hepatic cystic Echinococcosis of CE1 stage in a healthy Japanese female that was suspected to have been acquired during her stay in the United Kingdom.The American journal of tropical medicine and hygiene · 2011Article
- Immunoglobulin G subclass responses to recombinant Em18 in the follow-up of patients with alveolar echinococcosis in different clinical stages.Clinical and vaccine immunology : CVI · 2010Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
An understanding of the correlation of the specific antibody responses and the disease phase is essential in evaluating diagnostic values of immunological tests in human echinococcosis. In this study, 422 echinococcosis patients diagnosed by ultrasonography, including 246 with cystic echinococcosis (CE), 173 with alveolar echinococcosis (AE), and 3 with dual infection, were tested for specific IgG in sera against recombinant AgB (rAgB) and recombinant Em18 (rEm18) in an enzyme-linked immunosorbent assay. As a result, rAgB-specific antibody was detected in 77.6% of CE and 86.1% of AE patients, while rEm18-specific antibody was present in 28.9% of CE and 87.3% of AE patients. Additionally, all three patients with dual infection exhibited specific antibodies responding to rAgB and rEm18. Further analysis revealed that rAgB-specific antibody was elevated in a significantly greater proportion (87.3%) of CE patients with cysts at active or transitional stages (CE1, CE2, or CE3), compared to 54.8% of other patients with cysts at an early or an inactive stage (CL or CE4 or CE5). Furthermore, rAgB-specific antibody was detected in 95.6% of CE2 cases, which was statistically greater than that (73.7%) in CE1 patients. Although rEm18-specific antibody was elevated in 28.9% of CE patients, the positive reaction was much weaker in CE than in AE cases. Serum levels and concentrations of rEm18-specific antibody were further indicated to be strongly disease phase correlated in AE patients, with positive rates of 97.4% in cases with alveolar lesions containing central necrosis and 66.7% in patients with early alveolar lesions that measured </=5 cm.
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