ArticleAmerican journal of physiology. Renal physiology2010
Role of 5-HT1A receptors in control of lower urinary tract function in anesthetized rats.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Assessment of overactive bladder in women antidepressant users.International urology and nephrology · 2015Trial
- Differential Effects of Antidepressants on Hypothalamic Serotonin Levels in Rats: An In Vivo Microdialysis Study.International neurourology journal · 2026Article
- The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function.Pharmacology research & perspectives · 2026Article
- The Association between Depression and Overactive Bladder: A Cross-Sectional Study of NHANES 2011-2018.International urogynecology journal · 2025Article
- Cariprazine for Clozapine-Induced Urinary Incontinence in Treatment-Resistant Depression: A Case Report.Cureus · 2025Article
- Fluoxetine, a selective serotonin reuptake inhibitor, versus desmopressin in primary monosymptomatic nocturnal enuresis: A randomised controlled trial.Arab journal of urology · 2025Article
- Long-Term 5-HTInternational journal of molecular sciences · 2024Article
- The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis.International neurourology journal · 2023Article
- Spinal interneurons of the lower urinary tract circuits.Autonomic neuroscience : basic & clinical · 2021Review
- Delivery of the 5-HTBiology · 2021Article
- Mapping of spinal interneurons involved in regulation of the lower urinary tract in juvenile male rats.IBRO reports · 2020Article
- Improvement of lower urinary tract function by a selective serotonin 5-HTExperimental neurology · 2020Article
- Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as αMolecules (Basel, Switzerland) · 2018Article
- Spinal Transection Alters External Urethral Sphincter Activity during Spontaneous Voiding in Freely Moving Rats.Journal of neurotrauma · 2017Article
- Evaluation of Overactive Bladder in Male Antidepressant Users: A Prospective Study.International neurourology journal · 2017Article
- A ventral root avulsion injury model for neurogenic underactive bladder studies.Experimental neurology · 2016Review
- Contribution of the external urethral sphincter to urinary void size in unanesthetized unrestrained rats.Neurourology and urodynamics · 2016Article
- Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats.American journal of translational research · 2016Article
- Spinal stimulation of the upper lumbar spinal cord modulates urethral sphincter activity in rats after spinal cord injury.American journal of physiology. Renal physiology · 2015Article
- The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice.Neurourology and urodynamics · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of 5-hydroxytryptamine (5-HT) 1A (5-HT1A) receptors in lower urinary tract function was examined in urethane-anesthetized female Sprague-Dawley rats. Bladder pressure and the external urethral sphincter electromyogram (EUS EMG) activity were recorded during continuous-infusion transvesical cystometrograms (TV-CMGs) to allow voiding and during transurethral-CMGs (TU-CMGs) which prevented voiding and allowed recording of isovolumetric bladder contractions. 8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, decreased volume threshold (VT) for initiating voiding and increased contraction amplitude (CA) during TU-CMGs but decreased CA during TV-CMGs. 8-OH-DPAT prolonged EUS bursting as well as the intrabursting silent periods (SP) during voiding. N-[2-[4-(2-methoxyphenyl)-1- piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamine trihydrochloride (WAY-100635), a 5-HT1A antagonist, increased VT, increased residual volume, markedly decreased voiding efficiency, decreased the amplitude of micturition contractions recorded under isovolumetric conditions, and decreased the SP of EUS bursting. These results indicate that activation of 5-HT1A receptors by endogenous 5-HT lowers the threshold for initiating reflex voiding and promotes voiding function by enhancing the duration of EUS relaxation, which should reduce urethral outlet resistance.
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