ArticleMolecular pain2009
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
Article in Molecular pain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Postoperative pain after different doses of remifentanil infusion during anaesthesia: a meta-analysis.BMC anesthesiology · 2024Pooled it
- Pooled it
- High-dose intraoperative remifentanil infusion increases early postoperative analgesic consumption: a prospective, randomized, double-blind controlled study.Journal of anesthesia · 2018Trial
- The Effect of Nefopam Infusion during Laparascopic Cholecystectomy on Postoperative Pain.International journal of medical sciences · 2017Trial
- Stepwise tapering of remifentanil at the end of surgery decreased postoperative pain and the need of rescue analgesics after thyroidectomy.BMC anesthesiology · 2015Trial
- Dorsal penile block of bupivacaine with adjuvant dexmedetomidine and dexamethasone can safely improve immediate post-operative analgesia and decrease opioid consumption after inflatable penile prosthesis surgery.International journal of impotence research · 2026Article
- Opiod-free anesthesia: the importance of evidence synthesis despite heterogeneity.Journal of anesthesia, analgesia and critical care · 2025Article
- Characterization and antioxidant activity of nano-formulated berberine and cyperus rotundus extracts with anti-inflammatory effects in mastitis-induced rats.Scientific reports · 2024Article
- Roles of Phosphorylation of N-Methyl-D-Aspartate Receptor in Chronic Pain.Cellular and molecular neurobiology · 2023Review
- Thalamocortical circuits drive remifentanil-induced postoperative hyperalgesia.The Journal of clinical investigation · 2022Article
- Beyond pain in the brain: A clinician's guide to interpreting the spinal cord's role in the pain experience.Musculoskeletal science & practice · 2022Article
- Pharmacological Interventions for Opioid-Induced Hyperalgesia: A Scoping Review of Preclinical Trials.Journal of clinical medicine · 2022Article
- Article
- Effects of Low-Dose Ketamine Infusion on Alleviating the Opioid Burden for Patients Undergoing Myomectomy Surgery.Turkish journal of anaesthesiology and reanimation · 2021Article
- Postoperative Nausea and Vomiting in Pediatric Patients.Paediatric drugs · 2021Review
- Patient and Surgery-Related Predictors of Acute Postoperative Pain.Current pain and headache reports · 2020Review
- Low-dose S+ ketamine in target-controlled intravenous anaesthesia with remifentanil and propofol for open gynaecological surgery: A randomised controlled trial.Indian journal of anaesthesia · 2019Article
- Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice.Frontiers in neurology · 2019Article
- The influence of dexmedetomidine on remifentanil-induced hyperalgesia and the sex differences.Experimental and therapeutic medicine · 2018Article
- Electro-acupuncture stimulation prevents remifentanil-induced postoperative hyperalgesia by suppressing spinal microglia in rats.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperimental and clinical studies showed that intraoperative infusion of remifentanil has been associated with postoperative hyperalgesia. Previous reports suggested that spinal N-methyl-D-aspartate (NMDA) receptors may contribute to the development and maintenance of opioid-induced hyperalgesia. In the present study, we used a rat model of postoperative pain to investigate the role of tyrosine phosphorylation of NMDA receptor 2B (NR2B) subunit in spinal cord in the postoperative hyperalgesia induced by remifentanil and the intervention of pretreatment with ketamine.
resultsIntraoperative infusion of remifentanil (0.04 mg/kg, subcutaneous) significantly enhanced mechanical allodynia and thermal hyperalgesia induced by the plantar incision during the postoperative period (each lasting between 2 h and 48 h), which was attenuated by pretreatment with ketamine (10 mg/kg, subcutaneous). Correlated with the pain behavior changes, immunocytochemical and western blotting experiments in our study revealed that there was a marked increase in NR2B phosphorylation at Tyr1472 in the superficial dorsal horn after intraoperative infusion of remifentanil, which was attenuated by pretreatment with ketamine.
conclusionsThis study provides direct evidence that tyrosine phosphorylation of the NR2B at Tyr1472 in spinal dosal horn contributes to postoperative hyperalgesia induced by remifentanil and supports the potential therapeutic value of ketamine for improving postoperative hyperalgesia induced by remifentanil.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.