ReviewCellular and molecular neurobiology2010
Biological mechanisms of physical activity in preventing cognitive decline.
Review in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04185298 (Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults With Mild Cognitive Impairment), which is not on this map. Cited by 137 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults With Mild Cognitive Impairment
Who cites it
137 citing papers in PubMed, 7 syntheses or guidelines pooled it, 364 citations in OpenAlex.
- A study on the effects of exercise training on cortical excitability in athletes: a meta-analysis based on TMS measurements.Frontiers in psychology · 2025Pooled it
- Comparing the efficacy of physical therapy interventions in Alzheimer's disease: a network meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- The Effects of Combined Physical and Cognitive Training on Inhibitory Control: A Systematic Review and Meta-Analysis.Neuroscience and biobehavioral reviews · 2021Pooled it
- Physical exercise is effective for neuropsychiatric symptoms in Alzheimer's disease: a systematic review.Arquivos de neuro-psiquiatria · 2021Pooled it
- Physical Activity for Executive Function and Activities of Daily Living in AD Patients: A Systematic Review and Meta-Analysis.Frontiers in psychology · 2020Pooled it
- Shared biological pathways for frailty and cognitive impairment: A systematic review.Ageing research reviews · 2018Pooled it
- Effects of Physical Activity Programs on the Improvement of Dementia Symptom: A Meta-Analysis.BioMed research international · 2016Pooled it
- Trial
- The effects of equine-assisted activities on execution function in children aged 7-8 years: A randomized controlled trial.Brain and behavior · 2023Trial
- The effects of a moderate physical activity intervention on physical fitness and cognition in healthy elderly with low levels of physical activity: a randomized controlled trial.Alzheimer's research & therapy · 2023Trial
- The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial.Alzheimer's research & therapy · 2019Trial
- Effects of simultaneously performed cognitive and physical training in older adults.BMC neuroscience · 2013Trial
- Preliminary Findings Describing Participant Experience With iSTEP, an mHealth Intervention to Increase Physical Activity and Improve Neurocognitive Function in People Living With HIV.The Journal of the Association of Nurses in AIDS Care : JANACTrial
- Observational
- Longitudinal changes in cognition, sleep, and psychological distress following the MORE program in head and neck cancer patients undergoing chemoradiotherapy.Scientific reports · 2026Article
- Associations of long-term PMBMC public health · 2026Article
- Editorial: The role of neurogenesis in cognitive decline during aging.Frontiers in genetics · 2026Article
- Exercise as a Promising Non-Pharmacological Intervention for ADHD.Revista de neurologia · 2025Article
- Associations of Wearable-Measured Sleep and Physical Activity With Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI.JMIR aging · 2025Observational
- Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.medRxiv : the preprint server for health sciences · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to guarantee better conditions for competition, the nervous system has developed not only mechanisms controlling muscle effectors, but also retrograde systems that, starting from peripheral structures, may influence brain functions. Under such perspective, physical activity could play an important role in influencing cognitive brain functions including learning and memory. The results of epidemiological studies (cross-sectional, prospective and retrospective) support a positive relationship between cognition and physical activities. Recent meta-analysis confirmed a significant effect of exercise on cognitive functions. However, the biological mechanisms that underlie such beneficial effects are still to be completely elucidated. They include supramolecular mechanisms (e.g. neurogenesis, synaptogenesis, and angiogenesis) which, in turn, are controlled by molecular mechanisms, such as BDNF, IGF-1, hormone and second messengers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.