ArticlePLoS genetics2009
Increased expression and protein divergence in duplicate genes is associated with morphological diversification.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Gene Families, Structural and Functional Contexts Shape Protein Thermostability and Paralog Divergence inPlants (Basel, Switzerland) · 2026Article
- Article
- Degree of Functional Divergence in Duplicates Is Associated with Distinct Roles in Plant Evolution.Molecular biology and evolution · 2021Article
- Protein patterns and their association with photosynthetic pigment content, agronomic behavior, and origin of purslane accessions (Biotechnologia · 2021Article
- The differential expression patterns of paralogs in response to stresses indicate expression and sequence divergences.BMC plant biology · 2020Article
- Expression Partitioning of Duplicate Genes at Single Cell Resolution inFrontiers in genetics · 2020Article
- Contribution of Functional Divergence Through Copy Number Variations to the Inter-Species and Intra-Species Diversity in Specialized Metabolites.Frontiers in plant science · 2019Article
- An evolutionary model motivated by physicochemical properties of amino acids reveals variation among proteins.Bioinformatics (Oxford, England) · 2018Article
- Functional divergence of duplicate genes several million years after gene duplication in Arabidopsis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Evolution of Gene Duplication in Plants.Plant physiology · 2016Review
- Expression divergence of cellulose synthase (CesA) genes after a recent whole genome duplication event in Populus.Planta · 2015Article
- Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.Nucleic acids research · 2014Article
- Tissue-specific profiling reveals transcriptome alterations in Arabidopsis mutants lacking morphological phenotypes.The Plant cell · 2013Article
- Genetic variation and expression diversity between grain and sweet sorghum lines.BMC genomics · 2013Article
- Human monogenic disease genes have frequently functionally redundant paralogs.PLoS computational biology · 2013Article
- Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses.BMC evolutionary biology · 2012Article
- Emerging knowledge from genome sequencing of crop species.Molecular biotechnology · 2012Review
- Interactome-wide prediction of protein-protein binding sites reveals effects of protein sequence variation in Arabidopsis thaliana.PloS one · 2012Article
- Evidence for network evolution in an Arabidopsis interactome map.Science (New York, N.Y.) · 2011Article
- Origin and evolution of genes related to ABA metabolism and its signaling pathways.Journal of plant research · 2011Article
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5 authors.
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Abstract
The differentiation of both gene expression and protein function is thought to be important as a mechanism of the functionalization of duplicate genes. However, it has not been addressed whether expression or protein divergence of duplicate genes is greater in those genes that have undergone functionalization compared with those that have not. We examined a total of 492 paralogous gene pairs associated with morphological diversification in a plant model organism (Arabidopsis thaliana). Classifying these paralogous gene pairs into high, low, and no morphological diversification groups, based on knock-out data, we found that the divergence rate of both gene expression and protein sequences were significantly higher in either high or low morphological diversification groups compared with those in the no morphological diversification group. These results strongly suggest that the divergence of both expression and protein sequence are important sources for morphological diversification of duplicate genes. Although both mechanisms are not mutually exclusive, our analysis suggested that changes of expression pattern play the minor role (33%-41%) and that changes of protein sequence play the major role (59%-67%) in morphological diversification. Finally, we examined to what extent duplicate genes are associated with expression or protein divergence exerting morphological diversification at the whole-genome level. Interestingly, duplicate genes randomly chosen from A. thaliana had not experienced expression or protein divergence that resulted in morphological diversification. These results indicate that most duplicate genes have experienced minor functionalization.
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