ArticlePloS one2009
Extraordinary molecular evolution in the PRDM9 fertility gene.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 76 citations in OpenAlex.
- The evolutionary entanglement of flipons with zinc fingers and retroelements has engendered a large family of Z-DNA and G-quadruplex binding proteins.Open biology · 2025Article
- Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence.eLife · 2023Article
- The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.International journal of molecular sciences · 2022Article
- Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila.Nucleic acids research · 2021Article
- Pinpointing theFrontiers in genetics · 2021Article
- Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.eLife · 2020Article
- Discovery of a chemical probe for PRDM9.Nature communications · 2019Article
- Molecular evolution of the meiotic recombination pathway in mammals.Evolution; international journal of organic evolution · 2019Article
- Historical Meiotic Crossover Hotspots Fueled Patterns of Evolutionary Divergence in Rice.The Plant cell · 2019Article
- PRDM9, a driver of the genetic map.PLoS genetics · 2018Review
- PRDM9 and Its Role in Genetic Recombination.Trends in genetics : TIG · 2018Review
- The consequences of sequence erosion in the evolution of recombination hotspots.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The PRDM9 KRAB domain is required for meiosis and involved in protein interactions.Chromosoma · 2017Article
- Structural basis of human PR/SET domain 9 (PRDM9) allele C-specific recognition of its cognate DNA sequence.The Journal of biological chemistry · 2017Article
- The potential of shifting recombination hotspots to increase genetic gain in livestock breeding.Genetics, selection, evolution : GSE · 2017Article
- The long zinc finger domain of PRDM9 forms a highly stable and long-lived complex with its DNA recognition sequence.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
- Ruminant-specific multiple duplication events of PRDM9 before speciation.BMC evolutionary biology · 2017Article
- Evolutionary dynamics of meiotic recombination hotspots regulator PRDM9 in bovids.Molecular genetics and genomics : MGG · 2017Article
- The pioneering role of PRDM9 indel mutations in tarsier evolution.Scientific reports · 2016Article
- Variant discovery and breakpoint region prediction for studying the human 22q11.2 deletion using BAC clone and whole genome sequencing analysis.Human molecular genetics · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Recent work indicates that allelic incompatibility in the mouse PRDM9 (Meisetz) gene can cause hybrid male sterility, contributing to genetic isolation and potentially speciation. The only phenotype of mouse PRDM9 knockouts is a meiosis I block that causes sterility in both sexes. The PRDM9 gene encodes a protein with histone H3(K4) trimethyltransferase activity, a KRAB domain, and a DNA-binding domain consisting of multiple tandem C2H2 zinc finger (ZF) domains. We have analyzed human coding polymorphism and interspecies evolutionary changes in the PRDM9 gene. The ZF domains of PRDM9 are evolving very rapidly, with compelling evidence of positive selection in primates. Positively selected amino acids are predominantly those known to make nucleotide specific contacts in C2H2 zinc fingers. These results suggest that PRDM9 is subject to recurrent selection to change DNA-binding specificity. The human PRDM9 protein is highly polymorphic in its ZF domains and nearly all polymorphisms affect the same nucleotide contact residues that are subject to positive selection. ZF domain nucleotide sequences are strongly homogenized within species, indicating that interfinger recombination contributes to their evolution. PRDM9 has previously been assumed to be a transcription factor required to induce meiosis specific genes, a role that is inconsistent with its molecular evolution. We suggest instead that PRDM9 is involved in some aspect of centromere segregation conflict and that rapidly evolving centromeric DNA drives changes in PRDM9 DNA-binding domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.